Projects per year
Personal profile
Research interests
My research focuses comparative glucocorticoid biology and in particular the role of glucocorticoid metabolism in health and disease. Working with experimental models, veterinary clinical cases and human data I investigate the relationships between glucocorticoid metabolism and the morbidities associated with obesity as well as the role of glucocorticoid and mineralocorticoid receptor activation in disease processes.
Projects
Wellcome Trust Clinical Career Development Fellowship Stage 2: Glucocorticoid metabolism; breaking the link between obesity and metabolic disease
Projects
The role of the liver in equine insulin dysregulation.
Projects
Boehringer Ingelheim opnME: Elucidating mechanisms of equine metabolic syndrome
Projects
Wellcome Trust Clinical Career Development Fellowship Stage 1: Carbonyl Reductase 1; a novel glucocorticoid metabolising enzyme
Teaching
Module Lead: Early Life Physiology
Contributors: Animal Physiology Systems 1 and 2
Supervision
Lisa Ivatt: BHF PhD: The role of peri-vascular adipose tissue in obesity-associated hypertension
Education/Academic qualification
PGCert , Post-Graduate Certificate in Academic Practice, University of Edinburgh
Award Date: 5 Sep 2020
PhD, Cortisol Dysregulation in Equine Endocrinopathic Laminitis, University of Edinburgh
Award Date: 1 Jun 2016
Master, Veterinary Sciences, University of Cambridge
Award Date: 1 Jun 2007
Bachelor, Veterinary Sciences
Award Date: 1 Jul 2003
External positions
Honorary Fellow, University of Edinburgh
1 Apr 2022 → …
Keywords
- QP Physiology
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Projects
- 1 Active
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Glucocorticoid metabolism; a hidden link between obesity and its consequences
1/08/22 → 31/07/26
Project: Research
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Carbonyl reductase 1 amplifies glucocorticoid action in adipose tissue and impairs glucose tolerance in lean mice
Bell, R. M. B., Villalobos, E., Nixon, M., Miguelez-Crespo, A., Murphy, L., Fawkes, A., Coutts, A., Sharp, M. G. F., Koerner, M. V., Allan, E., Meijer, O. C., Houtman, R., Odermatt, A., Beck, K. R., Denham, S. G., Lee, P., Homer, N. Z. M., Walker, B. R. & Morgan, R. A., Jun 2021, In: Molecular Metabolism. 48, 101225.Research output: Contribution to journal › Article › peer-review
Open Access -
Dysregulation of cortisol metabolism in equine pituitary pars intermedia dysfunction
Morgan, R. A., Keen, J. A., Homer, N., Nixon, M., McKinnon-Garvin, A. M., Moses-Williams, J. A., Davis, S. R., Hadoke, P. W. F. & Walker, B. R., Nov 2018, In: Endocrinology. 159, 11, p. 3791-3800 10 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Citations (Scopus) -
Quantitative analysis of 11-dehydrocorticosterone and corticosterone for preclinical studies by liquid chromatography/triple quadrupole mass spectrometry
Verma, M., Sooy, K., Just, G., Nixon, M., Morgan, R., Andrew, R., Chapman, K. E. & Homer, N. Z. M., Sep 2020, In: Rapid Communications in Mass Spectrometry. 34, Suppl 4, e8610.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (Scopus) -
Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity
Morgan, R. A., Beck, K. R., Nixon, M., Homer, N. Z. M., Crawford, A. A., Melchers, D., Houtman, R., Meijer, O. C., Stomby, A., Anderson, A. J., Upreti, R., Stimson, R. H., Olsson, T., Michoel, T., Cohain, A., Ruusalepp, A., Schadt, E. E., Björkegren, J. L. M., Andrew, R., Kenyon, C. J., & 4 others, 6 Sep 2017, In: Scientific Reports. 7, 10633.Research output: Contribution to journal › Article › peer-review
Open Access11 Citations (Scopus) -
Species-specific regulation of angiogenesis by glucocorticoids reveals contrasting effects on inflammatory and angiogenic pathways
Morgan, R., Halligan, D., O’Callaghan, A., Andrew, R., Livingstone, D., Abernethie, A., Maltese, G., Walker, B. & Hadoke, P., Feb 2018, In: PLoS ONE. e0192746.Research output: Contribution to journal › Article › peer-review
Open Access8 Citations (Scopus)