674. Understanding the genetic architecture of claw horn lesions in different lactation stages in Holstein cattle

B. Li; M. Barden; V. Kapsona; E.S. Molano; A. Anagnostopoulos; B.E. Griffiths; C. Bedford; X. Dai; M. Coffey; A. Psifidi; G. Oikonomou; G. Banos

doi:10.3920/978-90-8686-940-4_674

674. Understanding the genetic architecture of claw horn lesions in different lactation stages in Holstein cattle

B. Li, M. Barden, V. Kapsona, E.S. Molano, A. Anagnostopoulos, B.E. Griffiths, C. Bedford, X. Dai, M. Coffey, A. Psifidi, G. Oikonomou, G. Banos

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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Abstract

Lameness in dairy cattle is primarily caused by foot lesions including sole haemorrhage (SH) and sole ulcers (SU). This study investigated the genetic architecture of SH and SU in different lactation stages based on accurate phenotyping, genetic parameter estimation, genome-wide association (GWA) and functional enrichment analyses. Foot lesion records were collected from 2,353 Holstein cows on four herds at four time-points: prior to calving, immediately after calving, early lactation, and late lactation stages. Heritability estimates were 0.11-0.20 for SH and 0.05-0.13 for SU across stages, and genetic correlations between stages were high for both traits. Candidate genes associated with SH and SU link to immune functions such as complement activation and inflammation, nervous system and muscle functions. To conclude, SH and SU are under genetic control and foot health can be improved with selective breeding.

Original language	English
Title of host publication	Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP)
Subtitle of host publication	Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges
Publisher	Wageningen Academic Publishers
Pages	2782-2785
ISBN (Electronic)	978-90-8686-940-4
DOIs	https://doi.org/10.3920/978-90-8686-940-4_674
Publication status	First published - 9 Feb 2023

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Li, B., Barden, M., Kapsona, V., Molano, E. S., Anagnostopoulos, A., Griffiths, B. E., Bedford, C., Dai, X., Coffey, M., Psifidi, A., Oikonomou, G., & Banos, G. (2023). 674. Understanding the genetic architecture of claw horn lesions in different lactation stages in Holstein cattle. In Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP): Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges (pp. 2782-2785). Wageningen Academic Publishers. Advance online publication. https://doi.org/10.3920/978-90-8686-940-4_674

Li, B. ; Barden, M. ; Kapsona, V. et al. / 674. Understanding the genetic architecture of claw horn lesions in different lactation stages in Holstein cattle. Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP): Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges. Wageningen Academic Publishers, 2023. pp. 2782-2785

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title = "674. Understanding the genetic architecture of claw horn lesions in different lactation stages in Holstein cattle",

abstract = "Lameness in dairy cattle is primarily caused by foot lesions including sole haemorrhage (SH) and sole ulcers (SU). This study investigated the genetic architecture of SH and SU in different lactation stages based on accurate phenotyping, genetic parameter estimation, genome-wide association (GWA) and functional enrichment analyses. Foot lesion records were collected from 2,353 Holstein cows on four herds at four time-points: prior to calving, immediately after calving, early lactation, and late lactation stages. Heritability estimates were 0.11-0.20 for SH and 0.05-0.13 for SU across stages, and genetic correlations between stages were high for both traits. Candidate genes associated with SH and SU link to immune functions such as complement activation and inflammation, nervous system and muscle functions. To conclude, SH and SU are under genetic control and foot health can be improved with selective breeding.",

author = "B. Li and M. Barden and V. Kapsona and E.S. Molano and A. Anagnostopoulos and B.E. Griffiths and C. Bedford and X. Dai and M. Coffey and A. Psifidi and G. Oikonomou and G. Banos",

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doi = "10.3920/978-90-8686-940-4_674",

language = "English",

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Li, B, Barden, M, Kapsona, V, Molano, ES, Anagnostopoulos, A, Griffiths, BE, Bedford, C, Dai, X, Coffey, M, Psifidi, A, Oikonomou, G & Banos, G 2023, 674. Understanding the genetic architecture of claw horn lesions in different lactation stages in Holstein cattle. in Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP): Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges. Wageningen Academic Publishers, pp. 2782-2785. https://doi.org/10.3920/978-90-8686-940-4_674

674. Understanding the genetic architecture of claw horn lesions in different lactation stages in Holstein cattle. / Li, B.; Barden, M.; Kapsona, V. et al.
Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP): Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges. Wageningen Academic Publishers, 2023. p. 2782-2785.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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T1 - 674. Understanding the genetic architecture of claw horn lesions in different lactation stages in Holstein cattle

AU - Li, B.

AU - Barden, M.

AU - Kapsona, V.

AU - Molano, E.S.

AU - Anagnostopoulos, A.

AU - Griffiths, B.E.

AU - Bedford, C.

AU - Dai, X.

AU - Coffey, M.

AU - Psifidi, A.

AU - Oikonomou, G.

AU - Banos, G.

PY - 2023/2/9

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N2 - Lameness in dairy cattle is primarily caused by foot lesions including sole haemorrhage (SH) and sole ulcers (SU). This study investigated the genetic architecture of SH and SU in different lactation stages based on accurate phenotyping, genetic parameter estimation, genome-wide association (GWA) and functional enrichment analyses. Foot lesion records were collected from 2,353 Holstein cows on four herds at four time-points: prior to calving, immediately after calving, early lactation, and late lactation stages. Heritability estimates were 0.11-0.20 for SH and 0.05-0.13 for SU across stages, and genetic correlations between stages were high for both traits. Candidate genes associated with SH and SU link to immune functions such as complement activation and inflammation, nervous system and muscle functions. To conclude, SH and SU are under genetic control and foot health can be improved with selective breeding.

AB - Lameness in dairy cattle is primarily caused by foot lesions including sole haemorrhage (SH) and sole ulcers (SU). This study investigated the genetic architecture of SH and SU in different lactation stages based on accurate phenotyping, genetic parameter estimation, genome-wide association (GWA) and functional enrichment analyses. Foot lesion records were collected from 2,353 Holstein cows on four herds at four time-points: prior to calving, immediately after calving, early lactation, and late lactation stages. Heritability estimates were 0.11-0.20 for SH and 0.05-0.13 for SU across stages, and genetic correlations between stages were high for both traits. Candidate genes associated with SH and SU link to immune functions such as complement activation and inflammation, nervous system and muscle functions. To conclude, SH and SU are under genetic control and foot health can be improved with selective breeding.

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Li B, Barden M, Kapsona V, Molano ES, Anagnostopoulos A, Griffiths BE et al. 674. Understanding the genetic architecture of claw horn lesions in different lactation stages in Holstein cattle. In Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP): Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges. Wageningen Academic Publishers. 2023. p. 2782-2785 Epub 2023 Feb 9. doi: 10.3920/978-90-8686-940-4_674

674. Understanding the genetic architecture of claw horn lesions in different lactation stages in Holstein cattle

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