A comprehensive review on biological properties of citrinin

José Williams Gomes de Oliveira Filho, Muhammad Torequl Islam, Eunus S. Ali, Shaikh Jamal Uddin, Jose Victor de Oliveira Santos, Marcus Vinícius Oliveira Barros de Alencar, Antonio Luiz Gomes Júnior, Márcia Fernanda Correia Jardim Paz, Maria dos Remédios Mendes de Brito, João Marcelo de Castro e Sousa, Subrata Shaw, Maria das Graças Freire de Medeiros, Sandra Maria Mendes de Moura Dantas, Hercília Maria Lins Rolim, Paulo Michel Pinheiro Ferreira, Mohammad Amjad Kamal, Magdalena D. Pieczynska, Niranjan Das, Vijai K. Gupta, Andrei MocanTeresinha de Jesus Aguiar dos Santos Andrade, Brahma Nand Singh, Siddhartha K. Mishra, Atanas G. Atanasov*, Ana Amélia de Carvalho Melo-Cavalcante

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

79 Citations (Scopus)


Citrinin (CIT) is a mycotoxin which causes contamination in the food and is associated with different toxic effects. A web search on CIT has been conducted covering the timespan since 1946. The accumulated data indicate that CIT is produced by several fungal strains belonging to Penicillium, Aspergillus and Monascus genera, and is usually found together with another nephrotoxic mycotoxin, ochratoxin A. Although, it is evident that CIT exposure can exert toxic effects on the heart, liver, kidney, as well as reproductive system, the mechanism of CIT-induced toxicity remains largely elusive. It is still controversial what are the genotoxic and mutagenic effects of CIT. Until now, its toxic effect has been linked to the CIT-mediated oxidative stress and mitochondrial dysfunction in biological systems. However, the toxicity strongly depends on its concentration, route, frequency and time of exposure, as well as from the used test systems. Besides the toxic effects, CIT is also reported to possess a broad spectrum of bioactivities, including antibacterial, antifungal, and potential anticancer and neuro-protective effects in vitro. This systematic review presents the current state of CIT research with emphasis on its bioactivity profile.

Original languageEnglish
Pages (from-to)130-141
Number of pages12
JournalFood and Chemical Toxicology
Early online date7 Oct 2017
Publication statusPrint publication - Dec 2017
Externally publishedYes


  • Anticancer
  • Antimicrobial
  • Citrinin
  • Genotoxicity
  • Mycotoxins
  • Toxicity


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