TY - JOUR
T1 - A comprehensive review on biological properties of citrinin
AU - de Oliveira Filho, José Williams Gomes
AU - Islam, Muhammad Torequl
AU - Ali, Eunus S.
AU - Uddin, Shaikh Jamal
AU - Santos, Jose Victor de Oliveira
AU - de Alencar, Marcus Vinícius Oliveira Barros
AU - Júnior, Antonio Luiz Gomes
AU - Paz, Márcia Fernanda Correia Jardim
AU - de Brito, Maria dos Remédios Mendes
AU - e Sousa, João Marcelo de Castro
AU - Shaw, Subrata
AU - de Medeiros, Maria das Graças Freire
AU - Dantas, Sandra Maria Mendes de Moura
AU - Rolim, Hercília Maria Lins
AU - Ferreira, Paulo Michel Pinheiro
AU - Kamal, Mohammad Amjad
AU - Pieczynska, Magdalena D.
AU - Das, Niranjan
AU - Gupta, Vijai K.
AU - Mocan, Andrei
AU - dos Santos Andrade, Teresinha de Jesus Aguiar
AU - Singh, Brahma Nand
AU - Mishra, Siddhartha K.
AU - Atanasov, Atanas G.
AU - Melo-Cavalcante, Ana Amélia de Carvalho
PY - 2017/12
Y1 - 2017/12
N2 - Citrinin (CIT) is a mycotoxin which causes contamination in the food and is associated with different toxic effects. A web search on CIT has been conducted covering the timespan since 1946. The accumulated data indicate that CIT is produced by several fungal strains belonging to Penicillium, Aspergillus and Monascus genera, and is usually found together with another nephrotoxic mycotoxin, ochratoxin A. Although, it is evident that CIT exposure can exert toxic effects on the heart, liver, kidney, as well as reproductive system, the mechanism of CIT-induced toxicity remains largely elusive. It is still controversial what are the genotoxic and mutagenic effects of CIT. Until now, its toxic effect has been linked to the CIT-mediated oxidative stress and mitochondrial dysfunction in biological systems. However, the toxicity strongly depends on its concentration, route, frequency and time of exposure, as well as from the used test systems. Besides the toxic effects, CIT is also reported to possess a broad spectrum of bioactivities, including antibacterial, antifungal, and potential anticancer and neuro-protective effects in vitro. This systematic review presents the current state of CIT research with emphasis on its bioactivity profile.
AB - Citrinin (CIT) is a mycotoxin which causes contamination in the food and is associated with different toxic effects. A web search on CIT has been conducted covering the timespan since 1946. The accumulated data indicate that CIT is produced by several fungal strains belonging to Penicillium, Aspergillus and Monascus genera, and is usually found together with another nephrotoxic mycotoxin, ochratoxin A. Although, it is evident that CIT exposure can exert toxic effects on the heart, liver, kidney, as well as reproductive system, the mechanism of CIT-induced toxicity remains largely elusive. It is still controversial what are the genotoxic and mutagenic effects of CIT. Until now, its toxic effect has been linked to the CIT-mediated oxidative stress and mitochondrial dysfunction in biological systems. However, the toxicity strongly depends on its concentration, route, frequency and time of exposure, as well as from the used test systems. Besides the toxic effects, CIT is also reported to possess a broad spectrum of bioactivities, including antibacterial, antifungal, and potential anticancer and neuro-protective effects in vitro. This systematic review presents the current state of CIT research with emphasis on its bioactivity profile.
KW - Anticancer
KW - Antimicrobial
KW - Citrinin
KW - Genotoxicity
KW - Mycotoxins
KW - Toxicity
UR - http://www.scopus.com/inward/record.url?scp=85031777451&partnerID=8YFLogxK
U2 - 10.1016/j.fct.2017.10.002
DO - 10.1016/j.fct.2017.10.002
M3 - Article
C2 - 28993214
AN - SCOPUS:85031777451
SN - 0278-6915
VL - 110
SP - 130
EP - 141
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
ER -