Age dependent changes in plasma creatine kinase activity in broiler chickens

MA Mitchell*, DA Sandercock

*Corresponding author for this work

Research output: Contribution to conferenceAbstractpeer-review


Plasma activity of the intracellular, muscle enzyme creatine kinase increases between 2 and 6 weeks of age in the modern broiler fowl. The corresponding activities in the circulation of the genetic predecessors of these birds in whom selection has been relaxed were lower at each age examined and the interline difference increased with time. In relaxed birds grown to the same final body weight as the selected animals enzyme activity was still significantly less. These trends were paralleled by plasma lactate dehydrogenase but not aspartate aminotransferase activities. The differences in plasma creatine kinase were not attributable to the tissue enzyme contents but are probably the result of efflux of the protein from muscle as a consequence of altered plasmalemmal integrity or permeability. The mechanism mediating this process awaits elucidation but increased membrane lipid oxidation attributable to different thyroid status in the two lines is unlikely as circulating thyroid hormone concentrations and chronological changes are similar in selected and relaxed birds.
Original languageEnglish
Number of pages2
Publication statusPrint publication - 12 Aug 1994
Externally publishedYes
Event9th European Poultry Conference of the WPSA 1994 - Glasgow, United Kingdom
Duration: 7 Aug 199412 Aug 1994


Conference9th European Poultry Conference of the WPSA 1994
Country/TerritoryUnited Kingdom
Internet address


  • Broiler chicken
  • Myopathy
  • Genetic selection
  • High growth rate
  • Muscle mass
  • Slow growing broiler line
  • Fast growing broiler line
  • Plasma CK activity
  • Creatine kinase
  • Lactate dehydrogenase
  • LDH
  • Aspartate aminotransferase
  • AST
  • Membrane lipid peroxidation
  • Muscle membrane integrity


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