TY - JOUR
T1 - AIE-featured tetraphenylethylene nanoarchitectures in biomedical application
T2 - Bioimaging, drug delivery and disease treatment
AU - Sharath Kumar, Kothanahally S.
AU - Girish, Yarabahally R.
AU - Ashrafizadeh, Milad
AU - Mirzaei, Sepideh
AU - Rakesh, Kadalipura P.
AU - Hossein Gholami, Mohammad
AU - Zabolian, Amirhossein
AU - Hushmandi, Kiavash
AU - Orive, Gorka
AU - Kadumudi, Firoz Babu
AU - Dolatshahi-Pirouz, Alireza
AU - Thakur, Vijay Kumar
AU - Zarrabi, Ali
AU - Makvandi, Pooyan
AU - Rangappa, Kanchugarakoppal S.
PY - 2021/11/15
Y1 - 2021/11/15
N2 - The development of aggregation-induced emission (AIE) has received extreme considerations from basic and clinical researches. To date, various luminogens with AIE property (AIEgens) have been broadly utilized in optoelectronic devices, fluorescent bio-probes, drug delivery, anticancer and chemosensors and many more. Scientists have likewise dedicated to investigating the possibilities of AIEgens in the biomedical field. Among the various AIE luminophores studied, tetraphenylethylene (TPE) derivatives have demonstrated as most promising AIEgen, owing to their capacity in self-organization and conjugation with aggregation-caused quenching (ACQ) fluorophores to form larger multi-component assemblies. It likewise generally utilized in different fields, like organic and therapeutic science, supramolecular chemistry, organic electronics, cancer therapy, apoptosis and inflammation, microorganism imaging therapy etc. This review encompasses the recent advances of TPE based AIE-active luminophores and their potential applications in biomolecular science.
AB - The development of aggregation-induced emission (AIE) has received extreme considerations from basic and clinical researches. To date, various luminogens with AIE property (AIEgens) have been broadly utilized in optoelectronic devices, fluorescent bio-probes, drug delivery, anticancer and chemosensors and many more. Scientists have likewise dedicated to investigating the possibilities of AIEgens in the biomedical field. Among the various AIE luminophores studied, tetraphenylethylene (TPE) derivatives have demonstrated as most promising AIEgen, owing to their capacity in self-organization and conjugation with aggregation-caused quenching (ACQ) fluorophores to form larger multi-component assemblies. It likewise generally utilized in different fields, like organic and therapeutic science, supramolecular chemistry, organic electronics, cancer therapy, apoptosis and inflammation, microorganism imaging therapy etc. This review encompasses the recent advances of TPE based AIE-active luminophores and their potential applications in biomolecular science.
KW - AIE
KW - Biomedical applications
KW - Luminogens
KW - Tetraphenylethylene
UR - http://www.scopus.com/inward/record.url?scp=85112756289&partnerID=8YFLogxK
U2 - 10.1016/j.ccr.2021.214135
DO - 10.1016/j.ccr.2021.214135
M3 - Review article
AN - SCOPUS:85112756289
SN - 0010-8545
VL - 447
JO - Coordination Chemistry Reviews
JF - Coordination Chemistry Reviews
M1 - 214135
ER -
