Analysis of single nucleotide polymorphisms variation associated with important economic and computed tomography measured traits in Texel sheep

D Garza Hernandez, S Mucha, G Banos, K Kaseja, KL Moore, NR Lambe, J Yates, L Bunger

Research output: Contribution to journalArticle

1 Citation (Scopus)
5 Downloads (Pure)

Abstract

Sheep are an important part of the global agricultural economy. Growth and meat production traits are significant economic traits in sheep. The Texel breed is the most popular terminal sire breed in the UK, mainly selected for muscle growth and lean carcasses. This is a study based on a genome-wide association approach that investigates the links between some economically important traits, including Computed Tomography (CT) measurements, and molecular polymorphisms in UK Texel sheep. Our main aim was to identify Single Nucleotide Polymorphisms (SNP) associated with growth, carcass, health and welfare traits of the Texel sheep breed. This study used data from 384 Texel rams. Data comprised 10 traits, including 2 CT measured traits. The phenotypic data were placed in four categories: growth traits, carcass traits, health traits and welfare traits. De-regressed estimated breeding values (EBV) for these traits together with sire genotypes derived with the Ovine 50K SNP array of Illumina were jointly analysed in a genome wide association analysis. Eight novel chromosome-wise significant associations were found for carcass, growth, health and welfare traits. Three significant markers were intronic variants and the remainder intergenic variants. This study is a first step to search for genomic regions controlling CT based productivity traits related to body and carcass composition in a terminal sire sheep breed using a 50K SNP genome-wide array. Results are important for the further development of strategies to identify causal variants associated with CT measures and other commercial traits in sheep. Independent studies are needed to confirm these results and identify candidate genes for the studied traits.
Original languageEnglish
Pages (from-to)915 - 922
Number of pages8
JournalAnimal
Volume12
Issue number5
Early online date17 Oct 2017
DOIs
Publication statusFirst published - 17 Oct 2017

Fingerprint

Texel
computed tomography
single nucleotide polymorphism
sheep
economics
sires
sheep breeds
breeds
genome
meat production
carcass composition
growth traits
breeding value
rams
carcass characteristics
body composition
genetic polymorphism
chromosomes
genomics
muscles

Bibliographical note

1020925

Keywords

  • Associated
  • CT
  • GWAS
  • Sheep
  • Texel

Cite this

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title = "Analysis of single nucleotide polymorphisms variation associated with important economic and computed tomography measured traits in Texel sheep",
abstract = "Sheep are an important part of the global agricultural economy. Growth and meat production traits are significant economic traits in sheep. The Texel breed is the most popular terminal sire breed in the UK, mainly selected for muscle growth and lean carcasses. This is a study based on a genome-wide association approach that investigates the links between some economically important traits, including Computed Tomography (CT) measurements, and molecular polymorphisms in UK Texel sheep. Our main aim was to identify Single Nucleotide Polymorphisms (SNP) associated with growth, carcass, health and welfare traits of the Texel sheep breed. This study used data from 384 Texel rams. Data comprised 10 traits, including 2 CT measured traits. The phenotypic data were placed in four categories: growth traits, carcass traits, health traits and welfare traits. De-regressed estimated breeding values (EBV) for these traits together with sire genotypes derived with the Ovine 50K SNP array of Illumina were jointly analysed in a genome wide association analysis. Eight novel chromosome-wise significant associations were found for carcass, growth, health and welfare traits. Three significant markers were intronic variants and the remainder intergenic variants. This study is a first step to search for genomic regions controlling CT based productivity traits related to body and carcass composition in a terminal sire sheep breed using a 50K SNP genome-wide array. Results are important for the further development of strategies to identify causal variants associated with CT measures and other commercial traits in sheep. Independent studies are needed to confirm these results and identify candidate genes for the studied traits.",
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Analysis of single nucleotide polymorphisms variation associated with important economic and computed tomography measured traits in Texel sheep. / Garza Hernandez, D; Mucha, S; Banos, G; Kaseja, K; Moore, KL; Lambe, NR; Yates, J; Bunger, L.

In: Animal, Vol. 12, No. 5, 17.10.2017, p. 915 - 922.

Research output: Contribution to journalArticle

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T1 - Analysis of single nucleotide polymorphisms variation associated with important economic and computed tomography measured traits in Texel sheep

AU - Garza Hernandez, D

AU - Mucha, S

AU - Banos, G

AU - Kaseja, K

AU - Moore, KL

AU - Lambe, NR

AU - Yates, J

AU - Bunger, L

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PY - 2017/10/17

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N2 - Sheep are an important part of the global agricultural economy. Growth and meat production traits are significant economic traits in sheep. The Texel breed is the most popular terminal sire breed in the UK, mainly selected for muscle growth and lean carcasses. This is a study based on a genome-wide association approach that investigates the links between some economically important traits, including Computed Tomography (CT) measurements, and molecular polymorphisms in UK Texel sheep. Our main aim was to identify Single Nucleotide Polymorphisms (SNP) associated with growth, carcass, health and welfare traits of the Texel sheep breed. This study used data from 384 Texel rams. Data comprised 10 traits, including 2 CT measured traits. The phenotypic data were placed in four categories: growth traits, carcass traits, health traits and welfare traits. De-regressed estimated breeding values (EBV) for these traits together with sire genotypes derived with the Ovine 50K SNP array of Illumina were jointly analysed in a genome wide association analysis. Eight novel chromosome-wise significant associations were found for carcass, growth, health and welfare traits. Three significant markers were intronic variants and the remainder intergenic variants. This study is a first step to search for genomic regions controlling CT based productivity traits related to body and carcass composition in a terminal sire sheep breed using a 50K SNP genome-wide array. Results are important for the further development of strategies to identify causal variants associated with CT measures and other commercial traits in sheep. Independent studies are needed to confirm these results and identify candidate genes for the studied traits.

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