TY - JOUR
T1 - Andrographolide, a diterpene lactone from Andrographis paniculata and its therapeutic promises in cancer
AU - Islam, Muhammad Torequl
AU - Ali, Eunüs S.
AU - Uddin, Shaikh Jamal
AU - Islam, Md Amirul
AU - Shaw, Subrata
AU - Khan, Ishaq N.
AU - Saravi, Seyed Soheil Saeedi
AU - Ahmad, Saheem
AU - Rehman, Shahnawaz
AU - Gupta, Vijai Kumar
AU - Găman, Mihnea Alexandru
AU - Găman, Amelia Maria
AU - Yele, Santosh
AU - Das, Asish Kumar
AU - de Castro e Sousa, João Marcelo
AU - de Moura Dantas, Sandra Maria Mendes
AU - Rolim, Hercília Maria Lins
AU - de Carvalho Melo-Cavalcante, Ana Amélia
AU - Mubarak, Mohammad S.
AU - Yarla, Nagendra Sastry
AU - Shilpi, Jamil A.
AU - Mishra, Siddhartha Kumar
AU - Atanasov, Atanas G.
AU - Kamal, Mohammad Amjad
PY - 2018/4/28
Y1 - 2018/4/28
N2 - The diterpene lactone andrographolide, isolated from Andrographis paniculata, has been proven to possess several important protective biological activities, including antioxidant, anti-inflammatory, immunomodulatory, antiseptic, antimicrobial, cytotoxic, hypolipidemic, cardioprotective, hepatoprotective, and neuroprotective effects. In addition, it has been reported to play a therapeutic role in the treatment of major human diseases, such as Parkinson's disease, rheumatoid arthritis, and colitis. This systematic review aims to highlight andrographolide as a promising agent in cancer treatment. To this purpose, a number of databases were used to search for the cytotoxic/anticancer effects of andrographolide in pre-clinical and clinical studies. Among 1703 identified literature articles, 139 were included in this review; 109 were investigated as non-clinical, whereas 24, 3, and 3 were pre-clinical, clinical, and non-pre-clinical trials, respectively. Among the model systems, cultured cell lines appeared as the most frequently (79.14%) used, followed by in vivo models using rodents, among others. Furthermore, andrographolide was found to exert cytotoxic/anticancer effects on almost all types of cell lines with the underlying mechanisms involving oxidative stress, cell cycle arrest, anti-inflammatory and immune system mediated effects, apoptosis, necrosis, autophagy, inhibition of cell adhesion, proliferation, migration, invasion, anti-angiogenic activity, and other miscellaneous actions. After careful consideration of the relevant evidence, we suggest that andrographolide can be one of the potential agents in the treatment of cancer in the near future.
AB - The diterpene lactone andrographolide, isolated from Andrographis paniculata, has been proven to possess several important protective biological activities, including antioxidant, anti-inflammatory, immunomodulatory, antiseptic, antimicrobial, cytotoxic, hypolipidemic, cardioprotective, hepatoprotective, and neuroprotective effects. In addition, it has been reported to play a therapeutic role in the treatment of major human diseases, such as Parkinson's disease, rheumatoid arthritis, and colitis. This systematic review aims to highlight andrographolide as a promising agent in cancer treatment. To this purpose, a number of databases were used to search for the cytotoxic/anticancer effects of andrographolide in pre-clinical and clinical studies. Among 1703 identified literature articles, 139 were included in this review; 109 were investigated as non-clinical, whereas 24, 3, and 3 were pre-clinical, clinical, and non-pre-clinical trials, respectively. Among the model systems, cultured cell lines appeared as the most frequently (79.14%) used, followed by in vivo models using rodents, among others. Furthermore, andrographolide was found to exert cytotoxic/anticancer effects on almost all types of cell lines with the underlying mechanisms involving oxidative stress, cell cycle arrest, anti-inflammatory and immune system mediated effects, apoptosis, necrosis, autophagy, inhibition of cell adhesion, proliferation, migration, invasion, anti-angiogenic activity, and other miscellaneous actions. After careful consideration of the relevant evidence, we suggest that andrographolide can be one of the potential agents in the treatment of cancer in the near future.
KW - Andrographis paniculata
KW - Andrographolide
KW - Anticancer
KW - Bioactive lactone
KW - Chemotherapy
KW - Diterpene lactone
UR - http://www.scopus.com/inward/record.url?scp=85041925701&partnerID=8YFLogxK
U2 - 10.1016/j.canlet.2018.01.074
DO - 10.1016/j.canlet.2018.01.074
M3 - Short survey
C2 - 29408515
AN - SCOPUS:85041925701
SN - 0304-3835
VL - 420
SP - 129
EP - 145
JO - Cancer Letters
JF - Cancer Letters
ER -
