TY - JOUR
T1 - Antioxidant capacity and combinatorial antimicrobial effects of Nardostachys jatamansi essential oil with conventional antibiotics against some drug resistant bacteria
AU - Majeed, Aasiya
AU - Guleria, Sanjay
AU - Sharma, Neha
AU - Salaria, Khalid Hussain
AU - Aiman, Faiqa
AU - Singh, Bikarma
AU - Gupta, Vijai Kumar
PY - 2023/1
Y1 - 2023/1
N2 - The antibacterial and antioxidant properties of essential oils (EOs) have long been recognized. The present study was conducted to investigate the antioxidant capability of Nardostachys jatamansi essential oil and to see if it has a synergistic antimicrobial effect with antibiotics against two Gram negative (Klebsiella pneumoniae and Escherichia coli) and three Gram positive (Bacillus subtilis, Micrococcus luteus and Staphylococcus aureus) bacterial strains. Guaia-6,9-diene (11.96 %), calarene (10.44 %), jatamansone (8.11 %), α-gurjunene (7.42 %), valencene (6.46 %), α-maaliene (5.24 %), sprojatamol (5.06 %), and caratol (5.06 %) were found to be the primary components of N. jatamansi EO. According to antioxidant studies, N. jatamansi EO has moderate DPPH radical scavenging activity, reducing power, and ferric reducing antioxidant power. Similarly, N. jatamansi EO also showed significant antibacterial activity, with inhibition zones, MIC, and MBC values ranging from 10.5 ± 0.5 to 14.0 ± 0.4 mm, 1.5 to 3.1 mg/mL, and 1.8 to 3.5 mg/mL respectively. The results of N. jatamansi EO interactions with conventional antibiotics revealed that amoxicillin, erythromycin, chloramphenicol, and ampicillin MICs were reduced by 5 to 10 fold, 4 to 9.09 fold, 4 to 10.5 fold, and 4 to 8.0 fold, respectively. The findings of this study are noteworthy because no previous reports of N. jatamansi EO's synergistic interaction with conventional antibiotics have been published, and therefore may constitute an important strategy for addressing problem of drug resistant bacteria.
AB - The antibacterial and antioxidant properties of essential oils (EOs) have long been recognized. The present study was conducted to investigate the antioxidant capability of Nardostachys jatamansi essential oil and to see if it has a synergistic antimicrobial effect with antibiotics against two Gram negative (Klebsiella pneumoniae and Escherichia coli) and three Gram positive (Bacillus subtilis, Micrococcus luteus and Staphylococcus aureus) bacterial strains. Guaia-6,9-diene (11.96 %), calarene (10.44 %), jatamansone (8.11 %), α-gurjunene (7.42 %), valencene (6.46 %), α-maaliene (5.24 %), sprojatamol (5.06 %), and caratol (5.06 %) were found to be the primary components of N. jatamansi EO. According to antioxidant studies, N. jatamansi EO has moderate DPPH radical scavenging activity, reducing power, and ferric reducing antioxidant power. Similarly, N. jatamansi EO also showed significant antibacterial activity, with inhibition zones, MIC, and MBC values ranging from 10.5 ± 0.5 to 14.0 ± 0.4 mm, 1.5 to 3.1 mg/mL, and 1.8 to 3.5 mg/mL respectively. The results of N. jatamansi EO interactions with conventional antibiotics revealed that amoxicillin, erythromycin, chloramphenicol, and ampicillin MICs were reduced by 5 to 10 fold, 4 to 9.09 fold, 4 to 10.5 fold, and 4 to 8.0 fold, respectively. The findings of this study are noteworthy because no previous reports of N. jatamansi EO's synergistic interaction with conventional antibiotics have been published, and therefore may constitute an important strategy for addressing problem of drug resistant bacteria.
KW - Antibiotics
KW - Antioxidant activity
KW - Nardostachys jatamansi
KW - Synergistic antimicrobial activity
UR - http://www.scopus.com/inward/record.url?scp=85144523122&partnerID=8YFLogxK
U2 - 10.1016/j.crbiot.2022.100118
DO - 10.1016/j.crbiot.2022.100118
M3 - Article
AN - SCOPUS:85144523122
SN - 2590-2628
VL - 5
JO - Current Research in Biotechnology
JF - Current Research in Biotechnology
M1 - 100118
ER -