Applications of fungal cellulases in biofuel production: Advances and limitations

Neha Srivastava, Manish Srivastava, P. K. Mishra*, Vijai K. Gupta, Gustavo Molina, Susana Rodriguez-Couto, Ambepu Manikanta, P. W. Ramteke

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

162 Citations (Scopus)


Nonrenewable fossil fuels and their serious environmental impact have forced to develop renewable & sustainable energy sources. In this scenario, cellulases have found extensive applications in the biofuel industries. Three main components of the cellulase enzymatic system, namely endoglucanase, exoglucanase and β-glycosidase, effectively convert cellulosic substrates into fermentable sugars. The commercial production of cellulase is currently performed under submerged fermentation (SmF) conditions using mesophilic microbial strains which are non-economic and also non-sustainable. Although, production of fungal cellulases using solid-state fermentation (SSF) is economically advantageous and a preferable route for industrial purposes, it suffers from a few bottlenecks (e.g. scale-up, difficult to control process parameters). Therefore, the present review provides an overview of the cost-effective and present scenario of cellulase production in the biofuel industries including recent advancements. In addition, the current limitations hampering the cost-effective production of cellulase have also been discussed to resolve them in the near future.

Original languageEnglish
Pages (from-to)2379-2386
Number of pages8
JournalRenewable and Sustainable Energy Reviews
Early online date1 Sept 2017
Publication statusPrint publication - Feb 2018
Externally publishedYes


  • Biofuel production
  • Cellulase
  • Fermentable sugars
  • Fungi
  • Solid-state fermentation
  • Submerged fermentation
  • Thermal dilution


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