Assessing the potential for Bluetongue virus 8 to spread and vaccination strategies in Scotland

PR Bessell, KR Searle, HK Auty, IG Handel, BV Purse, BM de C Bronsvoort

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Abstract

Europe has seen frequent outbreaks of Bluetongue (BT) disease since 2006, including an outbreak of BT virus serotype 8 in central France during 2015 that has continued to spread in Europe during 2016. Thus, assessing the potential for BTv-8 spread and determining the optimal deployment of vaccination is critical for contingency planning. We developed a spatially explicit mathematical model of BTv-8 spread in Scotland and explored the sensitivity of transmission to key disease spread parameters for which detailed empirical data is lacking. With parameters at mean values, there is little spread of BTv-8 in Scotland. However, under a “worst case” but still feasible scenario with parameters at the limits of their ranges and temperatures 1 °C warmer than the mean, we find extensive spread with 203,000 sheep infected given virus introduction to the south of Scotland between mid-May and mid-June. Strategically targeted vaccine interventions can greatly reduce BT spread. Specifically, despite BT having most clinical impact in sheep, we show that vaccination can have the greatest impact on reducing BTv infections in sheep when administered to cattle, which has implications for disease control policy.
Original languageEnglish
JournalScientific Reports
Volume6
Issue number38940
Early online date13 Dec 2016
DOIs
Publication statusFirst published - 13 Dec 2016

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Bluetongue
Bluetongue virus
Scotland
Sheep
Vaccination
Disease Outbreaks
France
Theoretical Models
Vaccines
Viruses
Temperature
Infection

Bibliographical note

1030832

Cite this

Bessell, PR., Searle, KR., Auty, HK., Handel, IG., Purse, BV., & de C Bronsvoort, BM. (2016). Assessing the potential for Bluetongue virus 8 to spread and vaccination strategies in Scotland. Scientific Reports, 6(38940). https://doi.org/10.1038/srep38940
Bessell, PR ; Searle, KR ; Auty, HK ; Handel, IG ; Purse, BV ; de C Bronsvoort, BM. / Assessing the potential for Bluetongue virus 8 to spread and vaccination strategies in Scotland. In: Scientific Reports. 2016 ; Vol. 6, No. 38940.
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Bessell, PR, Searle, KR, Auty, HK, Handel, IG, Purse, BV & de C Bronsvoort, BM 2016, 'Assessing the potential for Bluetongue virus 8 to spread and vaccination strategies in Scotland', Scientific Reports, vol. 6, no. 38940. https://doi.org/10.1038/srep38940

Assessing the potential for Bluetongue virus 8 to spread and vaccination strategies in Scotland. / Bessell, PR; Searle, KR; Auty, HK; Handel, IG; Purse, BV; de C Bronsvoort, BM.

In: Scientific Reports, Vol. 6, No. 38940, 13.12.2016.

Research output: Contribution to journalArticle

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Bessell PR, Searle KR, Auty HK, Handel IG, Purse BV, de C Bronsvoort BM. Assessing the potential for Bluetongue virus 8 to spread and vaccination strategies in Scotland. Scientific Reports. 2016 Dec 13;6(38940). https://doi.org/10.1038/srep38940