Association between PrP genotypes and performance traits in a Welsh Mountain flock

TC Pritchard, Christine Cahalan, Ioan Ap Dewi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The profile of scrapie has risen in recent years, with increasing public awareness that it is a disease that resembles BSE (bovine spongiform encephalopathy) in cattle and CJD (Creutzfeldt Jakob disease) in man. Eradication of scrapie is part of an EU control programme, to protect against the theoretical risk that BSE is present in sheep and goat populations, masked as scrapie. Major government intervention to bring scrapie under control has been a combination of selecting more resistant stock and closer surveillance of sheep and goat populations. Following recommendations of the Spongiform Encephalopathy Advisory Committee (SEAC), the UK National Scrapie Plan (NSP) was launched in July 2001 with the aim of increasing genetic resistance to scrapie. The genotypes that confer resistance/susceptibility to scrapie are categorised into five groups (Dawson et al ., 1998; Warner, 2003) (Group I5highest resistance, Group V5lowest resistance), and not only reflect potential resistance/susceptibility but also the potential for breeding animals to transfer alleles for resistance/susceptibility to their offspring.
Original languageEnglish
Pages (from-to)1421-1426
Number of pages6
JournalAnimal
Volume2
Issue number10
DOIs
Publication statusPrint publication - Oct 2008
Externally publishedYes

Fingerprint

Welsh Mountain
scrapie
flocks
genotype
bovine spongiform encephalopathy
goats
Creutzfeldt-Jakob Syndrome
sheep
prion diseases
animal breeding
genetic resistance
committees
alleles
monitoring
cattle

Keywords

  • Performance traits
  • PrP genotype
  • Scrapie
  • Welsh Mountain sheep

Cite this

Pritchard, TC ; Cahalan, Christine ; Ap Dewi, Ioan . / Association between PrP genotypes and performance traits in a Welsh Mountain flock. In: Animal. 2008 ; Vol. 2, No. 10. pp. 1421-1426.
@article{9ca80e2fd49f45bb8e2d9c97442b4d1d,
title = "Association between PrP genotypes and performance traits in a Welsh Mountain flock",
abstract = "The profile of scrapie has risen in recent years, with increasing public awareness that it is a disease that resembles BSE (bovine spongiform encephalopathy) in cattle and CJD (Creutzfeldt Jakob disease) in man. Eradication of scrapie is part of an EU control programme, to protect against the theoretical risk that BSE is present in sheep and goat populations, masked as scrapie. Major government intervention to bring scrapie under control has been a combination of selecting more resistant stock and closer surveillance of sheep and goat populations. Following recommendations of the Spongiform Encephalopathy Advisory Committee (SEAC), the UK National Scrapie Plan (NSP) was launched in July 2001 with the aim of increasing genetic resistance to scrapie. The genotypes that confer resistance/susceptibility to scrapie are categorised into five groups (Dawson et al ., 1998; Warner, 2003) (Group I5highest resistance, Group V5lowest resistance), and not only reflect potential resistance/susceptibility but also the potential for breeding animals to transfer alleles for resistance/susceptibility to their offspring.",
keywords = "Performance traits, PrP genotype, Scrapie, Welsh Mountain sheep",
author = "TC Pritchard and Christine Cahalan and {Ap Dewi}, Ioan",
year = "2008",
month = "10",
doi = "10.1017/S1751731108002747",
language = "English",
volume = "2",
pages = "1421--1426",
journal = "Animal",
issn = "1751-7311",
publisher = "Cambridge University Press",
number = "10",

}

Association between PrP genotypes and performance traits in a Welsh Mountain flock. / Pritchard, TC; Cahalan, Christine; Ap Dewi, Ioan .

In: Animal, Vol. 2, No. 10, 10.2008, p. 1421-1426.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association between PrP genotypes and performance traits in a Welsh Mountain flock

AU - Pritchard, TC

AU - Cahalan, Christine

AU - Ap Dewi, Ioan

PY - 2008/10

Y1 - 2008/10

N2 - The profile of scrapie has risen in recent years, with increasing public awareness that it is a disease that resembles BSE (bovine spongiform encephalopathy) in cattle and CJD (Creutzfeldt Jakob disease) in man. Eradication of scrapie is part of an EU control programme, to protect against the theoretical risk that BSE is present in sheep and goat populations, masked as scrapie. Major government intervention to bring scrapie under control has been a combination of selecting more resistant stock and closer surveillance of sheep and goat populations. Following recommendations of the Spongiform Encephalopathy Advisory Committee (SEAC), the UK National Scrapie Plan (NSP) was launched in July 2001 with the aim of increasing genetic resistance to scrapie. The genotypes that confer resistance/susceptibility to scrapie are categorised into five groups (Dawson et al ., 1998; Warner, 2003) (Group I5highest resistance, Group V5lowest resistance), and not only reflect potential resistance/susceptibility but also the potential for breeding animals to transfer alleles for resistance/susceptibility to their offspring.

AB - The profile of scrapie has risen in recent years, with increasing public awareness that it is a disease that resembles BSE (bovine spongiform encephalopathy) in cattle and CJD (Creutzfeldt Jakob disease) in man. Eradication of scrapie is part of an EU control programme, to protect against the theoretical risk that BSE is present in sheep and goat populations, masked as scrapie. Major government intervention to bring scrapie under control has been a combination of selecting more resistant stock and closer surveillance of sheep and goat populations. Following recommendations of the Spongiform Encephalopathy Advisory Committee (SEAC), the UK National Scrapie Plan (NSP) was launched in July 2001 with the aim of increasing genetic resistance to scrapie. The genotypes that confer resistance/susceptibility to scrapie are categorised into five groups (Dawson et al ., 1998; Warner, 2003) (Group I5highest resistance, Group V5lowest resistance), and not only reflect potential resistance/susceptibility but also the potential for breeding animals to transfer alleles for resistance/susceptibility to their offspring.

KW - Performance traits

KW - PrP genotype

KW - Scrapie

KW - Welsh Mountain sheep

U2 - 10.1017/S1751731108002747

DO - 10.1017/S1751731108002747

M3 - Article

VL - 2

SP - 1421

EP - 1426

JO - Animal

JF - Animal

SN - 1751-7311

IS - 10

ER -