The plasma membrane acts as one of the first lines of defense by establishing a physical barrier against microbes. Nevertheless, bacteria have developed a range of strategies to invade the host tissues efficiently. In this chapter, we focus on this understudied area and describe how bacteria target or redirect host membrane lipids. Domains enriched in sterols and sphingolipids, denominated membrane rafts, in particular, have been reported to be exploited by numerous bacterial pathogens. We will first describe the different strategies employed by bacteria to specifically target the PM via membrane rafts and non-raft counterpart domains; and secondly, we illustrate how development of biomimetic membranes has identified bacterial mechanisms of interaction.
|Title of host publication
|Health Consequences of Microbial Interactions with Hydrocarbons, Oils, and Lipids
|Place of Publication
|Print publication - 27 Sept 2019
|Handbook of Hydrocarbon and Lipid Microbiology