Bactericidal, quorum quenching and anti-biofilm nanofactories: a new niche for nanotechnologists

Brahma N. Singh, Prateeksha, Dalip K. Upreti, Braj Raj Singh, Tom Defoirdt, Vijai K. Gupta*, Ana Olivia De Souza, Harikesh Bahadur Singh, João C.M. Barreira, Isabel C.F.R. Ferreira, Khabat Vahabi

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

26 Citations (Scopus)

Abstract

Despite several conventional potent antibacterial therapies, bacterial infections pose a significant threat to human health because they are emerging as the leading cause of death worldwide. Due to the development of antibiotic resistance in bacteria, there is a pressing demand to discover novel approaches for developing more effective therapies to treat multidrug-resistant bacterial strains and biofilm-associated infections. Therefore, attention has been especially devoted to a new and emerging branch of science “nanotechnology” to design non-conventional antimicrobial chemotherapies. A range of nanomaterials and nano-sized carriers for conventional antimicrobial agents have fully justified their potential to combat bacterial diseases by reducing cell viability, by attenuating quorum sensing, and by inhibiting/or eradicating biofilms. This communication summarizes emerging nano-antimicrobial therapies in treating bacterial infections, particularly using antibacterial, quorum quenching, and anti-biofilm nanomaterials as new approaches to tackle the current challenges in combating infectious diseases.

Original languageEnglish
Pages (from-to)525-540
Number of pages16
JournalCritical Reviews in Biotechnology
Volume37
Issue number4
Early online date10 Aug 2016
DOIs
Publication statusPrint publication - 19 May 2017
Externally publishedYes

Keywords

  • anti-biofilm
  • Antibacterial
  • nanomaterials
  • nanotoxicology
  • quorum quenching

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