Berberine, a popular dietary supplement for human and animal health: Quantitative research literature analysis – a review

Andy Wai Kan Yeung*, Ilkay Erdogan Orhan, Bharat Bhushan Aggarwal, Maurizio Battino, Tarun Belwal, Anupam Bishayee, Maria Daglia, Hari Prasad Devkota, Amr El-Demerdash, Aneliya A. Balacheva, Maya G. Georgieva, Vijai Kumar Gupta, Jarosław Olav Horbańczuk, Artur Jóźwik, Ioana Mozos, Seyed Mohammad Nabavi, Valeria Pittala, Joanna Feder-Kubis, Ana Sanches Silva, Helen SheridanAntoni Sureda, Dongdong Wang, Volkmar Weissig, Yang Yang, Gökhan Zengin, Karuna Shanker, Mohammad Amin Moosavi, Muhammad Ajmal Shah, Fuad Al-Rimawi, Alessandra Durazzo, Massimo Lucarini, Eliana B. Souto, Antonello Santini, Dimitar Djilianov, Niranjan Das, Efstathia P. Skotti, Anna Wieczorek, Malgorzata Lysek-Gladysinska, Monika Michalczuk, Dominik Sieroń, Olaf K. Horbanczuk, Nikolay T. Tzvetkov, Atanas G. Atanasov

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

25 Citations (Scopus)


Berberine is an alkaloid with a wide range of reported beneficial health effects. The current work provides an extensive literature analysis on berberine. Bibliometric data were identified by means of the search string TOPIC=(“berberin*” OR “umbellatine*”), which yielded 5,547 publications indexed in the Web of Science Core Collection electronic database. The VOSviewer software generated bubble maps to visualize semantic terms with citation results. The ratio of original articles to reviews was 13.6:1. The literature has been growing more quickly since the 2010s. Major contributing countries were China, the United States, India, Japan, and South Korea. Most of the publications appeared in journals specialized in pharmacology pharmacy, biochemistry molecular biology, chemistry, and plant science. Some of the frequently mentioned chemicals/chemical classes were alkaloid, palmatine, jatrorrhizine, coptisine, isoquinoline, and sanguinarine. The prevalent medical conditions under investigation included Alzheimer’s disease, cancer, diabetes, and obesity.

Original languageEnglish
Pages (from-to)5-19
Number of pages15
JournalAnimal Science Papers and Reports
Issue number1
Publication statusPrint publication - 2020
Externally publishedYes


  • Alkaloid
  • Alzheimer’s disease
  • Berberine
  • Bibliometrics
  • Citation analysis
  • Diabetes
  • Obesity
  • VOSviewer
  • Web of Science


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