Bioactivity and In Silico Studies of Isoquinoline and Related Alkaloids as Promising Antiviral Agents: An Insight

Divya Sharma, Neetika Sharma, Namish Manchanda, Satyendra K. Prasad, Prabodh Chander Sharma, Vijay Kumar Thakur*, M. Mukhlesur Rahman, Mahaveer Dhobi*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)
14 Downloads (Pure)

Abstract

Viruses are widely recognized as the primary cause of infectious diseases around the world. The ongoing global pandemic due to the emergence of SARS-CoV-2 further added fuel to the fire. The development of therapeutics becomes very difficult as viruses can mutate their genome to become more complex and resistant. Medicinal plants and phytocompounds could be alternative options. Isoquinoline and their related alkaloids are naturally occurring compounds that interfere with multiple pathways including nuclear factor-κB, mitogen-activated protein kinase/extracellular-signal-regulated kinase, and inhibition of Ca2+-mediated fusion. These pathways play a crucial role in viral replication. Thus, the major goal of this study is to comprehend the function of various isoquinoline and related alkaloids in viral infections by examining their potential mechanisms of action, structure-activity relationships (SAR), in silico (particularly for SARS-CoV-2), in vitro and in vivo studies. The current advancements in isoquinoline and related alkaloids as discussed in the present review could facilitate an in-depth understanding of their role in the drug discovery process.
Original languageEnglish
Article number17
JournalBiomolecules
Volume13
Issue number1
Early online date21 Dec 2022
DOIs
Publication statusFirst published - 21 Dec 2022

Keywords

  • isoquinoline and related alkaloid
  • BBI
  • anti-viral
  • SARS-CoV-2
  • COVID-19
  • Humans
  • Antiviral Agents/pharmacology
  • Viruses
  • Alkaloids/pharmacology
  • Isoquinolines/pharmacology

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