TY - JOUR
T1 - Biodiversity, Biochemical Profiling, and Pharmaco-Commercial Applications of Withania somnifera
T2 - A Review
AU - Gaurav, Harshita
AU - Yadav, Divyanshu
AU - Maurya, Ankita
AU - Yadav, Himanshu
AU - Yadav, Ramanand
AU - Shukla, Amritesh Chandra
AU - Sharma, Minaxi
AU - Gupta, Vijai Kumar
AU - Palazon, Javier
PY - 2023/1/26
Y1 - 2023/1/26
N2 - Withania somnifera L. Dunal (Ashwagandha), a key medicinal plant native to India, is used globally to manage various ailments. This review focuses on the traditional uses, botany, phytochemistry, and pharmacological advances of its plant-derived constituents. It has been reported that at least 62 crucial and 48 inferior primary and secondary metabolites are present in the W. somnifera leaves, and 29 among these found in its roots and leaves are chiefly steroidal compounds, steroidal lactones, alkaloids, amino acids, etc. In addition, the whole shrub parts possess various medicinal activities such as anti-leukotriene, antineoplastic, analgesic, anti-oxidant, immunostimulatory, and rejuvenating properties, mainly observed by in vitro demonstration. However, the course of its medical use remains unknown. This review provides a comprehensive understanding of W. somnifera, which will be useful for mechanism studies and potential medical applications of W. somnifera, as well as for the development of a rational quality control system for W. somnifera as a therapeutic material in the future.
AB - Withania somnifera L. Dunal (Ashwagandha), a key medicinal plant native to India, is used globally to manage various ailments. This review focuses on the traditional uses, botany, phytochemistry, and pharmacological advances of its plant-derived constituents. It has been reported that at least 62 crucial and 48 inferior primary and secondary metabolites are present in the W. somnifera leaves, and 29 among these found in its roots and leaves are chiefly steroidal compounds, steroidal lactones, alkaloids, amino acids, etc. In addition, the whole shrub parts possess various medicinal activities such as anti-leukotriene, antineoplastic, analgesic, anti-oxidant, immunostimulatory, and rejuvenating properties, mainly observed by in vitro demonstration. However, the course of its medical use remains unknown. This review provides a comprehensive understanding of W. somnifera, which will be useful for mechanism studies and potential medical applications of W. somnifera, as well as for the development of a rational quality control system for W. somnifera as a therapeutic material in the future.
KW - ashwagandha
KW - botany
KW - pharmacological and biological activity
KW - phytochemistry
KW - traditional use
KW - Withania somnifera
UR - http://www.scopus.com/inward/record.url?scp=85147895162&partnerID=8YFLogxK
U2 - 10.3390/molecules28031208
DO - 10.3390/molecules28031208
M3 - Review article
C2 - 36770874
AN - SCOPUS:85147895162
SN - 1420-3049
VL - 28
JO - Molecules
JF - Molecules
IS - 3
M1 - 1208
ER -