Biodiversity, Biochemical Profiling, and Pharmaco-Commercial Applications of Withania somnifera: A Review

Harshita Gaurav, Divyanshu Yadav, Ankita Maurya, Himanshu Yadav, Ramanand Yadav, Amritesh Chandra Shukla, Minaxi Sharma, Vijai Kumar Gupta, Javier Palazon

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)
111 Downloads (Pure)

Abstract

Withania somnifera L. Dunal (Ashwagandha), a key medicinal plant native to India, is used globally to manage various ailments. This review focuses on the traditional uses, botany, phytochemistry, and pharmacological advances of its plant-derived constituents. It has been reported that at least 62 crucial and 48 inferior primary and secondary metabolites are present in the W. somnifera leaves, and 29 among these found in its roots and leaves are chiefly steroidal compounds, steroidal lactones, alkaloids, amino acids, etc. In addition, the whole shrub parts possess various medicinal activities such as anti-leukotriene, antineoplastic, analgesic, anti-oxidant, immunostimulatory, and rejuvenating properties, mainly observed by in vitro demonstration. However, the course of its medical use remains unknown. This review provides a comprehensive understanding of W. somnifera, which will be useful for mechanism studies and potential medical applications of W. somnifera, as well as for the development of a rational quality control system for W. somnifera as a therapeutic material in the future.

Original languageEnglish
Article number1208
JournalMolecules
Volume28
Issue number3
Early online date26 Jan 2023
DOIs
Publication statusFirst published - 26 Jan 2023

Keywords

  • ashwagandha
  • botany
  • pharmacological and biological activity
  • phytochemistry
  • traditional use
  • Withania somnifera

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