Biogenic Preparation, Characterization, and Biomedical Applications of Chitosan Functionalized Iron Oxide Nanocomposite

Devaraj Bharathi, Ranjithkumar Rajamani, Belay Zeleke Sibuh, Soumya Pandit, Sharad Agrawal, Neeraj Mishra, Mohit Sahni, Vijay Kumar Thakur*, Piyush Kumar Gupta*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

Chitosan (CS) functionalization over nanomaterials has gained more attention in the biomedical field due to their biocompatibility, biodegradability, and enhanced properties. In the present study, CS functionalized iron (II) oxide nanocomposite (CS/FeO NC) was prepared using Sida acuta leaf extract by a facile and eco-friendly green chemistry route. Phyto-compounds of S. acuta leaf were used as a reductant to prepare CS/FeO NC. The existence of CS and FeO crystalline peaks in CS/FeO NC was confirmed by XRD. FE-SEM analysis revealed that the prepared CS/FeO NC were spherical with a 10−100 nm average size. FTIR analyzed the existence of CS and metal-oxygen bands in the prepared NC. The CS/FeO NC showed the potential bactericidal activity against E. coli, B. subtilis, and S. aureus pathogens. Further, CS/FeO NC also exhibited the dose-dependent anti-proliferative property against human lung cancer cells (A549). Thus, the obtained outcomes revealed that the prepared CS/FeO NC could be a promising candidate in the biomedical sector to inhibit the growth of bacterial pathogens and lung cancer cells.
Original languageEnglish
Article number120
Number of pages11
JournalJournal of Composites Science
Volume6
Issue number5
Early online date22 Apr 2022
DOIs
Publication statusFirst published - 22 Apr 2022

Keywords

  • chitosan
  • FeO
  • nanocomposite
  • antibacterial
  • anticancer

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