Biotechnological and industrial applications of Streptomyces metabolites

Khushboo, Punit Kumar, Kashyap K. Dubey*, Zeba Usmani, Minaxi Sharma, Vijai Kumar Gupta*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Streptomyces sp. produces clinically important bioactive compounds with anticancer, antiviral, and antibacterial properties. These compounds have important roles in various fields like agriculture, and medicine, with bio-economic benefits. Progress in genome mining has resulted in the characterization of various secondary metabolites such as lipstatin, macrolide lactones, clavulanic acid, and cholesterol oxidase. Integration of DNA sequencing with computational tools has provided information regarding the biosynthetic pathways of secondary metabolites. This information is leading to the modulation of associated metabolic pathways to expand the biotechnological and industrial applications of metabolites. The increased utilization of bioactive compounds requires sustainable production to improve the bioeconomy. In this review, the authors discuss the bioactive compounds isolated from Streptomyces and advanced approaches to improve their production.

Original languageEnglish
Number of pages21
JournalBiofuels, Bioproducts and Biorefining
Early online date5 Oct 2021
DOIs
Publication statusFirst published - 5 Oct 2021

Keywords

  • antibiotics
  • cholesterol oxidase
  • lipstatin
  • macrolide lactones
  • Streptomyces

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