Carboxymethyl cellulose based sustainable hydrogel for colon-specific delivery of gentamicin

Ankit Verma*, Bhawna Sharma, Susheel Kalia, Walaa Fahad Alsanie, Sourbh Thakur, Vijay Kumar Thakur

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The current research includes the synthesis, improvement of NaCMC-cl-DMAA/AAc hydrogel and in-situ controlled release of gentamicin within various pH environments. The prepared hydrogel was then modified using boron nitride nanosheets aiming to enhancement in the adsorption rate. The prepared hydrogels were investigated by FTIR, XRD, FESEM, TGA/DSC, swelling and cell viability analysis. Cytotoxicity study indicated that prepared sample has a cytocompatibility nature towards healthy normal human cell line (FR2 cells). By changing the pH environment, the drug release properties of the hydrogels can be controlled. The cumulative rate of release for NaCMC-cl-DMAA/AAc hydrogel was 76.5 % at pH = 2.2 and 87.5 % at pH = 7.4. Whereas drug release rate for NaCMC-cl-DMAA/AAc-BNNSs hydrogel composite was 78.6 % at pH = 2.2 and 97.3 % at pH = 7.4 within 4320 min. Gentamicin release kinetics have been determined using the Korsemeyar-Peppas model, which confirms the drug release mechanism.

Original languageEnglish
Pages (from-to)773-782
Number of pages10
JournalInternational Journal of Biological Macromolecules
Volume228
Early online date30 Dec 2022
DOIs
Publication statusFirst published - 30 Dec 2022

Bibliographical note

Copyright © 2022. Published by Elsevier B.V.

Keywords

  • Boron nitride nanosheets
  • Carboxymethyl cellulose-based hydrogel
  • Gentamicin
  • Hydrogel nanocomposite
  • In-vitro drug loading and release

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