Differential susceptibility of catheter biomaterials to biofilm-associated infections and their remedy by drug-encapsulated eudragit RL100 nanoparticles

Vivek Kumar Pandey*, Kumar Rohit Srivastava, Gufran Ajmal, Vijay Kumar Thakur, Vijai Kumar Gupta, Siddh Nath Upadhyay, Pradeep Kumar Mishra

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Biofilms are the cause of major bacteriological infections in patients. The complex architecture of Escherichia coli (E. coli) biofilm attached to the surface of catheters has been studied and found to depend on the biomaterial’s surface properties. The SEM micrographs and water contact angle analysis have revealed that the nature of the surface affects the growth and extent of E. coli biofilm formation. In vitro studies have revealed that the Gram-negative E. coli adherence to implanted biomaterials takes place in accordance with hydrophobicity, i.e., latex > silicone > polyurethane > stainless steel. Permanent removal of E. coli biofilm requires 50 to 200 times more gentamicin sulfate (G-S) than the minimum inhibitory concentration (MIC) to remove 90% of E. coli biofilm (MBIC90). Here, in vitro eradication of biofilm-associated infection on biomaterials has been done by Eudragit RL100 encapsulated gentamicin sulfate (E-G-S) nanoparticle of range 140 nm. It is 10–20 times more effective against E. coli biofilm-associated infections eradication than normal unentrapped G-S. Thus, Eudragit RL100 mediated drug delivery system provides a promising way to reduce the cost of treatment with a higher drug therapeutic index.

Original languageEnglish
Article number5110
JournalInternational Journal of Molecular Sciences
Volume20
Issue number20
Early online date15 Oct 2019
DOIs
Publication statusFirst published - 15 Oct 2019
Externally publishedYes

Keywords

  • Antibiotics
  • Biofilm
  • Biomaterials
  • Catheters
  • E. coli
  • Nanoparticle-mediated drug delivery

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