Differentially expressed mRNAs, proteins and miRNAs associated to energy metabolism in skeletal muscle of beef cattle identified for low and high residual feed intake

Elisa B Carvalho, Mateus P Gionbelli, Rafael TS Rodrigues, Sarah FM Bonilha, Charles J Newbold, Simone EF Guimarães, Walmir Silva, Lucas L Verardo, Fabyano F Silva, Edenio Detmann, Marcio S Duarte*

*Corresponding author for this work

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Abstract

Feed efficiency is one of the most important parameters that affect beef production costs. The energy metabolism of skeletal muscle greatly contributes to variations in feed efficiency. However, information regarding differences in proteins involved in the energy metabolism of the skeletal muscle in beef cattle divergently identified for feed efficiency is scarce. In this study, we aimed to investigate energy metabolism of skeletal muscle of Nellore beef cattle, identified for low and high residual feed intake using a proteomics approach. We further assessed the expression of candidate microRNAs as a one of the possible mechanisms controlling the biosynthesis of the proteins involved in energy metabolism that were differentially abundant between high and low residual feed intake animals.
Original languageEnglish
Article number501
JournalBMC Genomics
Volume20
Issue number1
Early online date17 Jun 2019
DOIs
Publication statusPrint publication - 17 Jun 2019

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MicroRNAs
Energy Metabolism
Skeletal Muscle
Messenger RNA
Proteins
Protein Biosynthesis
Proteomics
Costs and Cost Analysis

Keywords

  • bovine
  • Feed efficiency
  • Muscle biology
  • Nellore
  • Proteomics

Cite this

Carvalho, Elisa B ; Gionbelli, Mateus P ; Rodrigues, Rafael TS ; Bonilha, Sarah FM ; Newbold, Charles J ; Guimarães, Simone EF ; Silva, Walmir ; Verardo, Lucas L ; Silva, Fabyano F ; Detmann, Edenio ; Duarte, Marcio S. / Differentially expressed mRNAs, proteins and miRNAs associated to energy metabolism in skeletal muscle of beef cattle identified for low and high residual feed intake. In: BMC Genomics. 2019 ; Vol. 20, No. 1.
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title = "Differentially expressed mRNAs, proteins and miRNAs associated to energy metabolism in skeletal muscle of beef cattle identified for low and high residual feed intake",
abstract = "Feed efficiency is one of the most important parameters that affect beef production costs. The energy metabolism of skeletal muscle greatly contributes to variations in feed efficiency. However, information regarding differences in proteins involved in the energy metabolism of the skeletal muscle in beef cattle divergently identified for feed efficiency is scarce. In this study, we aimed to investigate energy metabolism of skeletal muscle of Nellore beef cattle, identified for low and high residual feed intake using a proteomics approach. We further assessed the expression of candidate microRNAs as a one of the possible mechanisms controlling the biosynthesis of the proteins involved in energy metabolism that were differentially abundant between high and low residual feed intake animals.",
keywords = "bovine, Feed efficiency, Muscle biology, Nellore, Proteomics",
author = "Carvalho, {Elisa B} and Gionbelli, {Mateus P} and Rodrigues, {Rafael TS} and Bonilha, {Sarah FM} and Newbold, {Charles J} and Guimar{\~a}es, {Simone EF} and Walmir Silva and Verardo, {Lucas L} and Silva, {Fabyano F} and Edenio Detmann and Duarte, {Marcio S}",
year = "2019",
month = "6",
day = "17",
doi = "10.1186/s12864-019-5890-z",
language = "English",
volume = "20",
journal = "BMC Genomics",
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Carvalho, EB, Gionbelli, MP, Rodrigues, RTS, Bonilha, SFM, Newbold, CJ, Guimarães, SEF, Silva, W, Verardo, LL, Silva, FF, Detmann, E & Duarte, MS 2019, 'Differentially expressed mRNAs, proteins and miRNAs associated to energy metabolism in skeletal muscle of beef cattle identified for low and high residual feed intake', BMC Genomics, vol. 20, no. 1, 501. https://doi.org/10.1186/s12864-019-5890-z

Differentially expressed mRNAs, proteins and miRNAs associated to energy metabolism in skeletal muscle of beef cattle identified for low and high residual feed intake. / Carvalho, Elisa B; Gionbelli, Mateus P; Rodrigues, Rafael TS; Bonilha, Sarah FM; Newbold, Charles J; Guimarães, Simone EF; Silva, Walmir; Verardo, Lucas L; Silva, Fabyano F; Detmann, Edenio; Duarte, Marcio S.

In: BMC Genomics, Vol. 20, No. 1, 501, 17.06.2019.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Differentially expressed mRNAs, proteins and miRNAs associated to energy metabolism in skeletal muscle of beef cattle identified for low and high residual feed intake

AU - Carvalho, Elisa B

AU - Gionbelli, Mateus P

AU - Rodrigues, Rafael TS

AU - Bonilha, Sarah FM

AU - Newbold, Charles J

AU - Guimarães, Simone EF

AU - Silva, Walmir

AU - Verardo, Lucas L

AU - Silva, Fabyano F

AU - Detmann, Edenio

AU - Duarte, Marcio S

PY - 2019/6/17

Y1 - 2019/6/17

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AB - Feed efficiency is one of the most important parameters that affect beef production costs. The energy metabolism of skeletal muscle greatly contributes to variations in feed efficiency. However, information regarding differences in proteins involved in the energy metabolism of the skeletal muscle in beef cattle divergently identified for feed efficiency is scarce. In this study, we aimed to investigate energy metabolism of skeletal muscle of Nellore beef cattle, identified for low and high residual feed intake using a proteomics approach. We further assessed the expression of candidate microRNAs as a one of the possible mechanisms controlling the biosynthesis of the proteins involved in energy metabolism that were differentially abundant between high and low residual feed intake animals.

KW - bovine

KW - Feed efficiency

KW - Muscle biology

KW - Nellore

KW - Proteomics

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