Differentially expressed mRNAs, proteins and miRNAs associated to energy metabolism in skeletal muscle of beef cattle identified for low and high residual feed intake

Elisa B Carvalho, Mateus P Gionbelli, Rafael TS Rodrigues, Sarah FM Bonilha, Charles J Newbold, Simone EF Guimarães, Walmir Silva, Lucas L Verardo, Fabyano F Silva, Edenio Detmann, Marcio S Duarte*

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Citations (Scopus)
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Abstract

Feed efficiency is one of the most important parameters that affect beef production costs. The energy metabolism of skeletal muscle greatly contributes to variations in feed efficiency. However, information regarding differences in proteins involved in the energy metabolism of the skeletal muscle in beef cattle divergently identified for feed efficiency is scarce. In this study, we aimed to investigate energy metabolism of skeletal muscle of Nellore beef cattle, identified for low and high residual feed intake using a proteomics approach. We further assessed the expression of candidate microRNAs as a one of the possible mechanisms controlling the biosynthesis of the proteins involved in energy metabolism that were differentially abundant between high and low residual feed intake animals.
Original languageEnglish
Article number501
JournalBMC Genomics
Volume20
Issue number1
Early online date17 Jun 2019
DOIs
Publication statusPrint publication - 17 Jun 2019

Keywords

  • bovine
  • Feed efficiency
  • Muscle biology
  • Nellore
  • Proteomics

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    Carvalho, E. B., Gionbelli, M. P., Rodrigues, R. TS., Bonilha, S. FM., Newbold, C. J., Guimarães, S. EF., Silva, W., Verardo, L. L., Silva, F. F., Detmann, E., & Duarte, M. S. (2019). Differentially expressed mRNAs, proteins and miRNAs associated to energy metabolism in skeletal muscle of beef cattle identified for low and high residual feed intake. BMC Genomics, 20(1), [501]. https://doi.org/10.1186/s12864-019-5890-z