Effect of sodium butyrate on performance, immune status, microarchitecture of small intestinal mucosa and lymphoid organs in broiler chickens

Arbab Sikandar*, Hafsa Zaneb, Muhammad Younus, Saima Masood, Asim Aslam, Farina Khattak, Saima Ashraf, Muhammad Shahbaz Yousaf, Habib Rehman

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Citations (Scopus)
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Abstract

Objective: This study aimed to examine the effect of sodium butyrate (SB) on growth performance, immune status, organs weights, and microarchitecture of lymphoid organs and small intestine. 

Methods: A total of 120, 1-d-old broiler chicks were distributed into the following four treatment groups: corn-soy based basal diet (BD) without supplement (control), or the same BD supplemented with 0.1 g/kg zinc bacitracin (ZnB), 0.5 g/kg SB (SB-0.5), or 1.0 g/kg SB (SB-1), respectively. Six birds/group were killed on d-21 and d-35, and samples were collected. 

Results: Cell-mediated immune response at 48 h post-Phytohemagglutinin-P injection, and antibody titer against Newcastle disease vaccine and sheep red blood cells on d-35 was noted higher (p<0.05) in SB-1 compared to ZnB and control. Lower (p<0.05) feed conversion ratio (FCR) was attained by the supplemented groups. Thymus and spleen weighed more (p<0.05) in SB-1, and bursa registered more (p<0.05) weight in both SB groups compared to control. On d-21, areas of thymus medulla and spleen germinal centers were noted higher (p<0.05) in SB-1 group. The villus height and villus surface area increased (p<0.05) in duodenum and jejunum in both SB groups on d-21, and in SB-1 on d-35, respectively compared to ZnB and control. On d-21, number of goblet cells containing mucins of acidic nature increased (p<0.05) in all the segments of small intestines in SB-1 group compared to control, and on d-35 in ileum compared to other groups. 

Conclusion: In conclusion, SB improved growth performance and immunity as well as modulated morphology of lymphoid organs and gut mucosa in broiler chickens.

Original languageEnglish
Pages (from-to)690-699
Number of pages10
JournalAsian-Australasian Journal of Animal Sciences
Volume30
Issue number5
Early online date13 Jan 2017
DOIs
Publication statusPrint publication - 1 May 2017

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Butyric Acid
Intestinal Mucosa
intestinal mucosa
Chickens
broiler chickens
Sodium
Bacitracin
bacitracin
Thymus
Zinc
zinc
villi
Nutrition
sodium butyrate
Mucous Membrane
Thymus Gland
Small Intestine
small intestine
growth performance
spleen

Keywords

  • Antibiotic growth promoter
  • Goblet cells
  • Intraepithelial lymphocytes
  • Mucosa
  • Organic acid
  • Poultry

Cite this

Sikandar, Arbab ; Zaneb, Hafsa ; Younus, Muhammad ; Masood, Saima ; Aslam, Asim ; Khattak, Farina ; Ashraf, Saima ; Yousaf, Muhammad Shahbaz ; Rehman, Habib. / Effect of sodium butyrate on performance, immune status, microarchitecture of small intestinal mucosa and lymphoid organs in broiler chickens. In: Asian-Australasian Journal of Animal Sciences. 2017 ; Vol. 30, No. 5. pp. 690-699.
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Effect of sodium butyrate on performance, immune status, microarchitecture of small intestinal mucosa and lymphoid organs in broiler chickens. / Sikandar, Arbab; Zaneb, Hafsa; Younus, Muhammad; Masood, Saima; Aslam, Asim; Khattak, Farina; Ashraf, Saima; Yousaf, Muhammad Shahbaz; Rehman, Habib.

In: Asian-Australasian Journal of Animal Sciences, Vol. 30, No. 5, 01.05.2017, p. 690-699.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of sodium butyrate on performance, immune status, microarchitecture of small intestinal mucosa and lymphoid organs in broiler chickens

AU - Sikandar, Arbab

AU - Zaneb, Hafsa

AU - Younus, Muhammad

AU - Masood, Saima

AU - Aslam, Asim

AU - Khattak, Farina

AU - Ashraf, Saima

AU - Yousaf, Muhammad Shahbaz

AU - Rehman, Habib

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Objective: This study aimed to examine the effect of sodium butyrate (SB) on growth performance, immune status, organs weights, and microarchitecture of lymphoid organs and small intestine. Methods: A total of 120, 1-d-old broiler chicks were distributed into the following four treatment groups: corn-soy based basal diet (BD) without supplement (control), or the same BD supplemented with 0.1 g/kg zinc bacitracin (ZnB), 0.5 g/kg SB (SB-0.5), or 1.0 g/kg SB (SB-1), respectively. Six birds/group were killed on d-21 and d-35, and samples were collected. Results: Cell-mediated immune response at 48 h post-Phytohemagglutinin-P injection, and antibody titer against Newcastle disease vaccine and sheep red blood cells on d-35 was noted higher (p<0.05) in SB-1 compared to ZnB and control. Lower (p<0.05) feed conversion ratio (FCR) was attained by the supplemented groups. Thymus and spleen weighed more (p<0.05) in SB-1, and bursa registered more (p<0.05) weight in both SB groups compared to control. On d-21, areas of thymus medulla and spleen germinal centers were noted higher (p<0.05) in SB-1 group. The villus height and villus surface area increased (p<0.05) in duodenum and jejunum in both SB groups on d-21, and in SB-1 on d-35, respectively compared to ZnB and control. On d-21, number of goblet cells containing mucins of acidic nature increased (p<0.05) in all the segments of small intestines in SB-1 group compared to control, and on d-35 in ileum compared to other groups. Conclusion: In conclusion, SB improved growth performance and immunity as well as modulated morphology of lymphoid organs and gut mucosa in broiler chickens.

AB - Objective: This study aimed to examine the effect of sodium butyrate (SB) on growth performance, immune status, organs weights, and microarchitecture of lymphoid organs and small intestine. Methods: A total of 120, 1-d-old broiler chicks were distributed into the following four treatment groups: corn-soy based basal diet (BD) without supplement (control), or the same BD supplemented with 0.1 g/kg zinc bacitracin (ZnB), 0.5 g/kg SB (SB-0.5), or 1.0 g/kg SB (SB-1), respectively. Six birds/group were killed on d-21 and d-35, and samples were collected. Results: Cell-mediated immune response at 48 h post-Phytohemagglutinin-P injection, and antibody titer against Newcastle disease vaccine and sheep red blood cells on d-35 was noted higher (p<0.05) in SB-1 compared to ZnB and control. Lower (p<0.05) feed conversion ratio (FCR) was attained by the supplemented groups. Thymus and spleen weighed more (p<0.05) in SB-1, and bursa registered more (p<0.05) weight in both SB groups compared to control. On d-21, areas of thymus medulla and spleen germinal centers were noted higher (p<0.05) in SB-1 group. The villus height and villus surface area increased (p<0.05) in duodenum and jejunum in both SB groups on d-21, and in SB-1 on d-35, respectively compared to ZnB and control. On d-21, number of goblet cells containing mucins of acidic nature increased (p<0.05) in all the segments of small intestines in SB-1 group compared to control, and on d-35 in ileum compared to other groups. Conclusion: In conclusion, SB improved growth performance and immunity as well as modulated morphology of lymphoid organs and gut mucosa in broiler chickens.

KW - Antibiotic growth promoter

KW - Goblet cells

KW - Intraepithelial lymphocytes

KW - Mucosa

KW - Organic acid

KW - Poultry

U2 - 10.5713/ajas.16.0824

DO - 10.5713/ajas.16.0824

M3 - Article

AN - SCOPUS:85018333265

VL - 30

SP - 690

EP - 699

JO - Asian-Australasian Journal of Animal Sciences

JF - Asian-Australasian Journal of Animal Sciences

SN - 1011-2367

IS - 5

ER -