TY - JOUR
T1 - Effects of Ascorbic Acid, Glutathione, Thiocyanate, and Iodide on Antimicrobial Activity of Acidified Nitrite
AU - Fite, Alemu
AU - Dykhuizen, Rolf
AU - Litterick, Audrey
AU - Golden, Michael
AU - Leifert, Carlo
PY - 2004/2/1
Y1 - 2004/2/1
N2 - It has been hypothesized that dietary nitrite augments the antimicrobial activity of gastric acid after conversion to nitric oxide and other reactive nitrogen intermediates, thus resulting in increased resistance against gastrointestinal infection. In this study, we showed that the reducing agents ascorbic acid and glutathione reduced the activity of acidified nitrite against Yersinia enterocolitica (P < 0.001). In contrast, iodide and thiocyanate increased the antimicrobial activity (P < 0.001), whereas hydroxyacids (citrate, lactate, and tartarate) had no measurable effects.
AB - It has been hypothesized that dietary nitrite augments the antimicrobial activity of gastric acid after conversion to nitric oxide and other reactive nitrogen intermediates, thus resulting in increased resistance against gastrointestinal infection. In this study, we showed that the reducing agents ascorbic acid and glutathione reduced the activity of acidified nitrite against Yersinia enterocolitica (P < 0.001). In contrast, iodide and thiocyanate increased the antimicrobial activity (P < 0.001), whereas hydroxyacids (citrate, lactate, and tartarate) had no measurable effects.
UR - http://www.scopus.com/inward/record.url?scp=0942301294&partnerID=8YFLogxK
U2 - 10.1128/AAC.48.2.655-658.2004
DO - 10.1128/AAC.48.2.655-658.2004
M3 - Article
C2 - 14742231
AN - SCOPUS:0942301294
SN - 0066-4804
VL - 48
SP - 655
EP - 658
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 2
ER -
