Effects of Ascorbic Acid, Glutathione, Thiocyanate, and Iodide on Antimicrobial Activity of Acidified Nitrite

Alemu Fite*, Rolf Dykhuizen, Audrey Litterick, Michael Golden, Carlo Leifert

*Corresponding author for this work

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

It has been hypothesized that dietary nitrite augments the antimicrobial activity of gastric acid after conversion to nitric oxide and other reactive nitrogen intermediates, thus resulting in increased resistance against gastrointestinal infection. In this study, we showed that the reducing agents ascorbic acid and glutathione reduced the activity of acidified nitrite against Yersinia enterocolitica (P < 0.001). In contrast, iodide and thiocyanate increased the antimicrobial activity (P < 0.001), whereas hydroxyacids (citrate, lactate, and tartarate) had no measurable effects.

Original languageEnglish
Pages (from-to)655-658
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume48
Issue number2
DOIs
Publication statusPrint publication - 1 Feb 2004

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