Epigenetic dysregulation in Epstein-Barr virus-associated gastric carcinoma: disease and treatments

Tung On Yau, Ceen-Ming Tang, Jun Yu

Research output: Contribution to journalReview articlepeer-review

43 Citations (Scopus)

Abstract

Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) comprises nearly 10% of gastric carcinoma cases worldwide. Recently, it was recognised to have unique clinicopathologic characteristics, including male predominance, lower rates of lymph node involvement, and better prognosis. EBVaGC is further characterised by abnormal hypermethylation of tumour suppressor gene promoter regions, causing down-regulation of their expression. In the present review, we critically discuss the role of EBV in gastric carcinogenesis, summarising the role of viral proteins and microRNAs with respect to aberrant methylation in EBVaGC. Given the role of epigenetic dysregulation in tumourigenesis, epigenetic modifiers may represent a novel therapeutic strategy.

Original languageEnglish
Pages (from-to)6448-56
Number of pages9
JournalWorld Journal of Gastroenterology
Volume20
Issue number21
DOIs
Publication statusPrint publication - 7 Jun 2014
Externally publishedYes

Keywords

  • CpG Islands
  • DNA Methylation
  • Epigenesis, Genetic
  • Epstein-Barr Virus Infections/complications
  • Gene Expression Regulation, Neoplastic
  • Genes, Tumor Suppressor
  • Herpesvirus 4, Human
  • Humans
  • MicroRNAs/metabolism
  • Prognosis
  • Stomach Neoplasms/complications
  • Viral Proteins/metabolism

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