Epigenetics and developmental programming of welfare and production traits in farm animals

KD Sinclair, KMD Rutherford, JM Wallace, JM Brameld, R Stoger, R Alberio, D Sweetman, DS Gardner, VEA Perry, CL Adam, CJ Ashworth, JE Robinson, CM Dwyer

Research output: Contribution to journalReview article

23 Citations (Scopus)
5 Downloads (Pure)

Abstract

The concept that postnatal health and development can be influenced by events that occur in utero originated from epidemiological studies in humans supported by numerous mechanistic (including epigenetic) studies in a variety of model species. Referred to as the ‘developmental origins of health and disease’ or ‘DOHaD’ hypothesis, the primary focus of large-animal studies until quite recently had been biomedical. Attention has since turned towards traits of commercial importance in farm animals. Herein we review the evidence that prenatal risk factors, including suboptimal parental nutrition, gestational stress, exposure to environmental chemicals and advanced breeding technologies, can determine traits such as postnatal growth, feed efficiency, milk yield, carcass composition, animal welfare and reproductive potential. We consider the role of epigenetic and cytoplasmic mechanisms of inheritance, and discuss implications for livestock production and future research endeavours. We conclude that although the concept is proven for several traits, issues relating to effect size, and hence commercial importance, remain. Studies have also invariably been conducted under controlled experimental conditions, frequently assessing single risk factors, thereby limiting their translational value for livestock production. We propose concerted international research efforts that consider multiple, concurrent stressors to better represent effects of contemporary animal production systems.
Original languageEnglish
Pages (from-to)1443 - 1478
Number of pages36
JournalReproduction, Fertility and Development
Volume28
Issue number10
Early online date21 Jul 2016
DOIs
Publication statusFirst published - 21 Jul 2016

Fingerprint

farmed animal species
epigenetics
risk factors
carcass composition
livestock production
animal production
animal welfare
epidemiological studies
milk yield
inheritance (genetics)
production technology
feed conversion
breeding
animals

Bibliographical note

2080039

Keywords

  • Behaviour
  • Fertility
  • Fetal programming
  • Lactation
  • Livestock
  • Nutrition
  • Stress

Cite this

Sinclair, KD ; Rutherford, KMD ; Wallace, JM ; Brameld, JM ; Stoger, R ; Alberio, R ; Sweetman, D ; Gardner, DS ; Perry, VEA ; Adam, CL ; Ashworth, CJ ; Robinson, JE ; Dwyer, CM. / Epigenetics and developmental programming of welfare and production traits in farm animals. In: Reproduction, Fertility and Development. 2016 ; Vol. 28, No. 10. pp. 1443 - 1478.
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Sinclair, KD, Rutherford, KMD, Wallace, JM, Brameld, JM, Stoger, R, Alberio, R, Sweetman, D, Gardner, DS, Perry, VEA, Adam, CL, Ashworth, CJ, Robinson, JE & Dwyer, CM 2016, 'Epigenetics and developmental programming of welfare and production traits in farm animals', Reproduction, Fertility and Development, vol. 28, no. 10, pp. 1443 - 1478. https://doi.org/10.1071/RD16102

Epigenetics and developmental programming of welfare and production traits in farm animals. / Sinclair, KD; Rutherford, KMD; Wallace, JM; Brameld, JM; Stoger, R; Alberio, R; Sweetman, D; Gardner, DS; Perry, VEA; Adam, CL; Ashworth, CJ; Robinson, JE; Dwyer, CM.

In: Reproduction, Fertility and Development, Vol. 28, No. 10, 21.07.2016, p. 1443 - 1478.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Epigenetics and developmental programming of welfare and production traits in farm animals

AU - Sinclair, KD

AU - Rutherford, KMD

AU - Wallace, JM

AU - Brameld, JM

AU - Stoger, R

AU - Alberio, R

AU - Sweetman, D

AU - Gardner, DS

AU - Perry, VEA

AU - Adam, CL

AU - Ashworth, CJ

AU - Robinson, JE

AU - Dwyer, CM

N1 - 2080039

PY - 2016/7/21

Y1 - 2016/7/21

N2 - The concept that postnatal health and development can be influenced by events that occur in utero originated from epidemiological studies in humans supported by numerous mechanistic (including epigenetic) studies in a variety of model species. Referred to as the ‘developmental origins of health and disease’ or ‘DOHaD’ hypothesis, the primary focus of large-animal studies until quite recently had been biomedical. Attention has since turned towards traits of commercial importance in farm animals. Herein we review the evidence that prenatal risk factors, including suboptimal parental nutrition, gestational stress, exposure to environmental chemicals and advanced breeding technologies, can determine traits such as postnatal growth, feed efficiency, milk yield, carcass composition, animal welfare and reproductive potential. We consider the role of epigenetic and cytoplasmic mechanisms of inheritance, and discuss implications for livestock production and future research endeavours. We conclude that although the concept is proven for several traits, issues relating to effect size, and hence commercial importance, remain. Studies have also invariably been conducted under controlled experimental conditions, frequently assessing single risk factors, thereby limiting their translational value for livestock production. We propose concerted international research efforts that consider multiple, concurrent stressors to better represent effects of contemporary animal production systems.

AB - The concept that postnatal health and development can be influenced by events that occur in utero originated from epidemiological studies in humans supported by numerous mechanistic (including epigenetic) studies in a variety of model species. Referred to as the ‘developmental origins of health and disease’ or ‘DOHaD’ hypothesis, the primary focus of large-animal studies until quite recently had been biomedical. Attention has since turned towards traits of commercial importance in farm animals. Herein we review the evidence that prenatal risk factors, including suboptimal parental nutrition, gestational stress, exposure to environmental chemicals and advanced breeding technologies, can determine traits such as postnatal growth, feed efficiency, milk yield, carcass composition, animal welfare and reproductive potential. We consider the role of epigenetic and cytoplasmic mechanisms of inheritance, and discuss implications for livestock production and future research endeavours. We conclude that although the concept is proven for several traits, issues relating to effect size, and hence commercial importance, remain. Studies have also invariably been conducted under controlled experimental conditions, frequently assessing single risk factors, thereby limiting their translational value for livestock production. We propose concerted international research efforts that consider multiple, concurrent stressors to better represent effects of contemporary animal production systems.

KW - Behaviour

KW - Fertility

KW - Fetal programming

KW - Lactation

KW - Livestock

KW - Nutrition

KW - Stress

U2 - 10.1071/RD16102

DO - 10.1071/RD16102

M3 - Review article

VL - 28

SP - 1443

EP - 1478

JO - Reproduction and Fertility Development

JF - Reproduction and Fertility Development

SN - 1031-3613

IS - 10

ER -