Estimating genetic and phenotypic parameters of cellular immune-associated traits in dairy cows

SJ Denholm, TN McNeilly, G Banos, MP Coffey, GC Russell, A Bagnall, MC Mitchell, E Wall

Research output: Contribution to journalArticle

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Abstract

Data collected from an experimental Holstein-Friesian research herd were used to determine genetic and phenotypic parameters of innate and adaptive cellular immune-associated traits. Relationships between immune-associated traits and production, health, and fertility traits were also investigated. Repeated blood leukocyte records were analyzed in 546 cows for 9 cellular immune-associated traits, including percent T cell subsets, B cells, NK cells, and granulocytes. Variance components were estimated by univariate analysis. Heritability estimates were obtained for all 9 traits, the highest of which were observed in the T cell subsets percent CD4+, percent CD8+, CD4+:CD8+ ratio, and percent NKp46+ cells (0.46, 0.41, 0.43 and 0.42, respectively), with between-individual variation accounting for 59 to 81% of total phenotypic variance. Associations between immune-associated traits and production, health, and fertility traits were investigated with bivariate analyses. Strong genetic correlations were observed between percent NKp46+ and stillbirth rate (0.61), and lameness episodes and percent CD8+ (−0.51). Regarding production traits, the strongest relationships were between CD4+:CD8+ ratio and weight phenotypes (−0.52 for live weight; −0.51 for empty body weight). Associations between feed conversion traits and immune-associated traits were also observed. Our results provide evidence that cellular immune-associated traits are heritable and repeatable, and the noticeable variation between animals would permit selection for altered trait values, particularly in the case of the T cell subsets. The associations we observed between immune-associated, health, fertility, and production traits suggest that genetic selection for cellular immune-associated traits could provide a useful tool in improving animal health, fitness, and fertility.
Original languageEnglish
Pages (from-to)1 - 2
Number of pages2
JournalJournal of Dairy Science
Volume100
Issue number4
Early online date26 Jan 2017
DOIs
Publication statusFirst published - 26 Jan 2017

Fingerprint

dairy cows
T-lymphocytes
genetic traits
body weight
fetal death
natural killer cells
granulocytes
phenotypic variation
animal health
lameness
genetic correlation
B-lymphocytes
leukocytes
heritability
Holstein
feed conversion
herds
phenotype
cows
blood

Bibliographical note

1024416
1030979
1031402

Keywords

  • Dairy cow
  • Heritability
  • Immune-associated trait
  • Variance

Cite this

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title = "Estimating genetic and phenotypic parameters of cellular immune-associated traits in dairy cows",
abstract = "Data collected from an experimental Holstein-Friesian research herd were used to determine genetic and phenotypic parameters of innate and adaptive cellular immune-associated traits. Relationships between immune-associated traits and production, health, and fertility traits were also investigated. Repeated blood leukocyte records were analyzed in 546 cows for 9 cellular immune-associated traits, including percent T cell subsets, B cells, NK cells, and granulocytes. Variance components were estimated by univariate analysis. Heritability estimates were obtained for all 9 traits, the highest of which were observed in the T cell subsets percent CD4+, percent CD8+, CD4+:CD8+ ratio, and percent NKp46+ cells (0.46, 0.41, 0.43 and 0.42, respectively), with between-individual variation accounting for 59 to 81{\%} of total phenotypic variance. Associations between immune-associated traits and production, health, and fertility traits were investigated with bivariate analyses. Strong genetic correlations were observed between percent NKp46+ and stillbirth rate (0.61), and lameness episodes and percent CD8+ (−0.51). Regarding production traits, the strongest relationships were between CD4+:CD8+ ratio and weight phenotypes (−0.52 for live weight; −0.51 for empty body weight). Associations between feed conversion traits and immune-associated traits were also observed. Our results provide evidence that cellular immune-associated traits are heritable and repeatable, and the noticeable variation between animals would permit selection for altered trait values, particularly in the case of the T cell subsets. The associations we observed between immune-associated, health, fertility, and production traits suggest that genetic selection for cellular immune-associated traits could provide a useful tool in improving animal health, fitness, and fertility.",
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Estimating genetic and phenotypic parameters of cellular immune-associated traits in dairy cows. / Denholm, SJ; McNeilly, TN; Banos, G; Coffey, MP; Russell, GC; Bagnall, A; Mitchell, MC; Wall, E.

In: Journal of Dairy Science, Vol. 100, No. 4, 26.01.2017, p. 1 - 2.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Estimating genetic and phenotypic parameters of cellular immune-associated traits in dairy cows

AU - Denholm, SJ

AU - McNeilly, TN

AU - Banos, G

AU - Coffey, MP

AU - Russell, GC

AU - Bagnall, A

AU - Mitchell, MC

AU - Wall, E

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PY - 2017/1/26

Y1 - 2017/1/26

N2 - Data collected from an experimental Holstein-Friesian research herd were used to determine genetic and phenotypic parameters of innate and adaptive cellular immune-associated traits. Relationships between immune-associated traits and production, health, and fertility traits were also investigated. Repeated blood leukocyte records were analyzed in 546 cows for 9 cellular immune-associated traits, including percent T cell subsets, B cells, NK cells, and granulocytes. Variance components were estimated by univariate analysis. Heritability estimates were obtained for all 9 traits, the highest of which were observed in the T cell subsets percent CD4+, percent CD8+, CD4+:CD8+ ratio, and percent NKp46+ cells (0.46, 0.41, 0.43 and 0.42, respectively), with between-individual variation accounting for 59 to 81% of total phenotypic variance. Associations between immune-associated traits and production, health, and fertility traits were investigated with bivariate analyses. Strong genetic correlations were observed between percent NKp46+ and stillbirth rate (0.61), and lameness episodes and percent CD8+ (−0.51). Regarding production traits, the strongest relationships were between CD4+:CD8+ ratio and weight phenotypes (−0.52 for live weight; −0.51 for empty body weight). Associations between feed conversion traits and immune-associated traits were also observed. Our results provide evidence that cellular immune-associated traits are heritable and repeatable, and the noticeable variation between animals would permit selection for altered trait values, particularly in the case of the T cell subsets. The associations we observed between immune-associated, health, fertility, and production traits suggest that genetic selection for cellular immune-associated traits could provide a useful tool in improving animal health, fitness, and fertility.

AB - Data collected from an experimental Holstein-Friesian research herd were used to determine genetic and phenotypic parameters of innate and adaptive cellular immune-associated traits. Relationships between immune-associated traits and production, health, and fertility traits were also investigated. Repeated blood leukocyte records were analyzed in 546 cows for 9 cellular immune-associated traits, including percent T cell subsets, B cells, NK cells, and granulocytes. Variance components were estimated by univariate analysis. Heritability estimates were obtained for all 9 traits, the highest of which were observed in the T cell subsets percent CD4+, percent CD8+, CD4+:CD8+ ratio, and percent NKp46+ cells (0.46, 0.41, 0.43 and 0.42, respectively), with between-individual variation accounting for 59 to 81% of total phenotypic variance. Associations between immune-associated traits and production, health, and fertility traits were investigated with bivariate analyses. Strong genetic correlations were observed between percent NKp46+ and stillbirth rate (0.61), and lameness episodes and percent CD8+ (−0.51). Regarding production traits, the strongest relationships were between CD4+:CD8+ ratio and weight phenotypes (−0.52 for live weight; −0.51 for empty body weight). Associations between feed conversion traits and immune-associated traits were also observed. Our results provide evidence that cellular immune-associated traits are heritable and repeatable, and the noticeable variation between animals would permit selection for altered trait values, particularly in the case of the T cell subsets. The associations we observed between immune-associated, health, fertility, and production traits suggest that genetic selection for cellular immune-associated traits could provide a useful tool in improving animal health, fitness, and fertility.

KW - Dairy cow

KW - Heritability

KW - Immune-associated trait

KW - Variance

U2 - 10.3168/jds.2016-11679

DO - 10.3168/jds.2016-11679

M3 - Article

VL - 100

SP - 1

EP - 2

JO - Journal of Dairy Science

JF - Journal of Dairy Science

SN - 0022-0302

IS - 4

ER -