Exploring the molecular mechanisms of increased intensity of pyrethroid resistance in Central African population of a major malaria vector Anopheles coluzzii

Amen N. Fadel; Sulaiman S. Ibrahim; Maurice M. Sandeu; Claudine Grâce Maffo Tatsinkou; Benjamin D. Menze; Helen Irving; Jack Hearn; Sanjay C. Nagi; Gareth D. Weedall; Ebai Terence; Williams Tchapga; Samuel Wanji; Charles S. Wondji

doi:10.1111/eva.13641

Exploring the molecular mechanisms of increased intensity of pyrethroid resistance in Central African population of a major malaria vector Anopheles coluzzii

Amen N. Fadel^*, Sulaiman S. Ibrahim^*, Maurice M. Sandeu, Claudine Grâce Maffo Tatsinkou, Benjamin D. Menze, Helen Irving, Jack Hearn, Sanjay C. Nagi, Gareth D. Weedall, Ebai Terence, Williams Tchapga, Samuel Wanji, Charles S. Wondji

^*Corresponding author for this work

Centre for Epidemiology and Planetary Health (CEPH)

Research output: Contribution to journal › Article › peer-review

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Abstract

Molecular mechanisms driving the escalation of pyrethroid resistance in the major malaria mosquitoes of Central Africa remain largely uncharacterized, hindering effective management strategies. Here, resistance intensity and the molecular mechanisms driving it were investigated in a population of Anopheles coluzzii from northern Cameroon. High levels of pyrethroid and organochloride resistance were observed in An. coluzzii population, with no mortality for 1× permethrin; only 11% and 33% mortalities for 5× and 10× permethrin diagnostic concentrations, and

Original language	English
Article number	e13641
Pages (from-to)	e13641
Journal	Evolutionary Applications
Volume	17
Issue number	2
Early online date	26 Feb 2024
DOIs	https://doi.org/10.1111/eva.13641
Publication status	Print publication - Feb 2024

Bibliographical note

Keywords

metabolic
Anopheles coluzzii
insecticide
Cameroon
resistance

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Fadel, A. N., Ibrahim, S. S., Sandeu, M. M., Tatsinkou, C. G. M., Menze, B. D., Irving, H., Hearn, J., Nagi, S. C., Weedall, G. D., Terence, E., Tchapga, W., Wanji, S., & Wondji, C. S. (2024). Exploring the molecular mechanisms of increased intensity of pyrethroid resistance in Central African population of a major malaria vector Anopheles coluzzii. Evolutionary Applications, 17(2), e13641. Article e13641. https://doi.org/10.1111/eva.13641

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title = "Exploring the molecular mechanisms of increased intensity of pyrethroid resistance in Central African population of a major malaria vector Anopheles coluzzii",

abstract = "Molecular mechanisms driving the escalation of pyrethroid resistance in the major malaria mosquitoes of Central Africa remain largely uncharacterized, hindering effective management strategies. Here, resistance intensity and the molecular mechanisms driving it were investigated in a population of Anopheles coluzzii from northern Cameroon. High levels of pyrethroid and organochloride resistance were observed in An. coluzzii population, with no mortality for 1× permethrin; only 11% and 33% mortalities for 5× and 10× permethrin diagnostic concentrations, and",

keywords = "metabolic, Anopheles coluzzii, insecticide, Cameroon, resistance",

author = "Fadel, {Amen N.} and Ibrahim, {Sulaiman S.} and Sandeu, {Maurice M.} and Tatsinkou, {Claudine Gr{\^a}ce Maffo} and Menze, {Benjamin D.} and Helen Irving and Jack Hearn and Nagi, {Sanjay C.} and Weedall, {Gareth D.} and Ebai Terence and Williams Tchapga and Samuel Wanji and Wondji, {Charles S.}",

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year = "2024",

month = feb,

doi = "10.1111/eva.13641",

language = "English",

volume = "17",

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Fadel, AN, Ibrahim, SS, Sandeu, MM, Tatsinkou, CGM, Menze, BD, Irving, H, Hearn, J, Nagi, SC, Weedall, GD, Terence, E, Tchapga, W, Wanji, S & Wondji, CS 2024, 'Exploring the molecular mechanisms of increased intensity of pyrethroid resistance in Central African population of a major malaria vector Anopheles coluzzii', Evolutionary Applications, vol. 17, no. 2, e13641, pp. e13641. https://doi.org/10.1111/eva.13641

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T1 - Exploring the molecular mechanisms of increased intensity of pyrethroid resistance in Central African population of a major malaria vector Anopheles coluzzii

AU - Fadel, Amen N.

AU - Ibrahim, Sulaiman S.

AU - Sandeu, Maurice M.

AU - Tatsinkou, Claudine Grâce Maffo

AU - Menze, Benjamin D.

AU - Irving, Helen

AU - Hearn, Jack

AU - Nagi, Sanjay C.

AU - Weedall, Gareth D.

AU - Terence, Ebai

AU - Tchapga, Williams

AU - Wanji, Samuel

AU - Wondji, Charles S.

PY - 2024/2

Y1 - 2024/2

N2 - Molecular mechanisms driving the escalation of pyrethroid resistance in the major malaria mosquitoes of Central Africa remain largely uncharacterized, hindering effective management strategies. Here, resistance intensity and the molecular mechanisms driving it were investigated in a population of Anopheles coluzzii from northern Cameroon. High levels of pyrethroid and organochloride resistance were observed in An. coluzzii population, with no mortality for 1× permethrin; only 11% and 33% mortalities for 5× and 10× permethrin diagnostic concentrations, and

AB - Molecular mechanisms driving the escalation of pyrethroid resistance in the major malaria mosquitoes of Central Africa remain largely uncharacterized, hindering effective management strategies. Here, resistance intensity and the molecular mechanisms driving it were investigated in a population of Anopheles coluzzii from northern Cameroon. High levels of pyrethroid and organochloride resistance were observed in An. coluzzii population, with no mortality for 1× permethrin; only 11% and 33% mortalities for 5× and 10× permethrin diagnostic concentrations, and

KW - metabolic

KW - Anopheles coluzzii

KW - insecticide

KW - Cameroon

KW - resistance

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DO - 10.1111/eva.13641

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SN - 1752-4571

VL - 17

SP - e13641

JO - Evolutionary Applications

JF - Evolutionary Applications

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M1 - e13641

ER -

Exploring the molecular mechanisms of increased intensity of pyrethroid resistance in Central African population of a major malaria vector Anopheles coluzzii

Abstract

Bibliographical note

Keywords

UN SDGs

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