Exploring the molecular mechanisms of increased intensity of pyrethroid resistance in Central African population of a major malaria vector Anopheles coluzzii

Amen N. Fadel*, Sulaiman S. Ibrahim*, Maurice M. Sandeu, Claudine Grâce Maffo Tatsinkou, Benjamin D. Menze, Helen Irving, Jack Hearn, Sanjay C. Nagi, Gareth D. Weedall, Ebai Terence, Williams Tchapga, Samuel Wanji, Charles S. Wondji

*Corresponding author for this work

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Abstract

Molecular mechanisms driving the escalation of pyrethroid resistance in the major malaria mosquitoes of Central Africa remain largely uncharacterized, hindering effective management strategies. Here, resistance intensity and the molecular mechanisms driving it were investigated in a population of Anopheles coluzzii from northern Cameroon. High levels of pyrethroid and organochloride resistance were observed in An. coluzzii population, with no mortality for 1× permethrin; only 11% and 33% mortalities for 5× and 10× permethrin diagnostic concentrations, and
Original languageEnglish
Article numbere13641
Pages (from-to)e13641
JournalEvolutionary Applications
Volume17
Issue number2
Early online date26 Feb 2024
DOIs
Publication statusPrint publication - Feb 2024

Bibliographical note

© 2024 The Authors. Evolutionary Applications published by John Wiley & Sons Ltd.

Keywords

  • metabolic
  • Anopheles coluzzii
  • insecticide
  • Cameroon
  • resistance

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