Factors associated with bovine neonatal pancytopenia (BNP) in calves: a case-control study

Sarah L Lambton; Adrian D Colloff; Richard P Smith; George L Caldow; Sandra F E Scholes; Kim Willoughby; Fiona Howie; Johanne Ellis-Iversen; Graham David; Alasdair J C Cook; Andrew Holliman

doi:10.1371/journal.pone.0034183

Factors associated with bovine neonatal pancytopenia (BNP) in calves: a case-control study

Sarah L Lambton, Adrian D Colloff, Richard P Smith, George L Caldow, Sandra F E Scholes, Kim Willoughby, Fiona Howie, Johanne Ellis-Iversen, Graham David, Alasdair J C Cook, Andrew Holliman

Veterinary Services

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Bovine neonatal pancytopenia (BNP; previously known as idiopathic haemorrhagic diathesis and commonly known as bleeding calf syndrome) is a novel haemorrhagic disease of young calves which has emerged in a number of European countries during recent years. Data were retrospectively collected during June to November 2010 for 56 case calves diagnosed with BNP between 17 March and 7 June of the same year. These were compared with 58 control calves randomly recruited from herds with no history of BNP. Multivariable logistic regression analysis showed that increased odds of a calf being a BNP case were associated with its dam having received PregSure® BVD (Pfizer Animal Health) vaccination prior to the birth of the calf (odds ratio (OR) 40.78, p<0.001) and its herd of origin being located in Scotland (OR 9.71, p = 0.006). Decreased odds of a calf being a BNP case were associated with the calf having been kept outside (OR 0.11, p = 0.006). The longer that a cattle herd had been established on the farm was also associated with decreased odds of a calf in that herd being a BNP case (OR 0.97, p = 0.011).

Original language	English
Article number	e34183
Journal	PLoS ONE
Volume	7
Issue number	5
DOIs	https://doi.org/10.1371/journal.pone.0034183
Publication status	Print publication - 11 May 2012

Keywords

Animals
Animals, Newborn
Case-Control Studies
Cattle
Cattle Diseases/etiology
Diarrhea Viruses, Bovine Viral/immunology
Female
Logistic Models
Male
Pancytopenia/etiology
Pregnancy
Retrospective Studies
Risk Factors
United Kingdom
Vaccination/adverse effects
Viral Vaccines/administration & dosage

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1371/journal.pone.0034183

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abstract = "Bovine neonatal pancytopenia (BNP; previously known as idiopathic haemorrhagic diathesis and commonly known as bleeding calf syndrome) is a novel haemorrhagic disease of young calves which has emerged in a number of European countries during recent years. Data were retrospectively collected during June to November 2010 for 56 case calves diagnosed with BNP between 17 March and 7 June of the same year. These were compared with 58 control calves randomly recruited from herds with no history of BNP. Multivariable logistic regression analysis showed that increased odds of a calf being a BNP case were associated with its dam having received PregSure{\textregistered} BVD (Pfizer Animal Health) vaccination prior to the birth of the calf (odds ratio (OR) 40.78, p<0.001) and its herd of origin being located in Scotland (OR 9.71, p = 0.006). Decreased odds of a calf being a BNP case were associated with the calf having been kept outside (OR 0.11, p = 0.006). The longer that a cattle herd had been established on the farm was also associated with decreased odds of a calf in that herd being a BNP case (OR 0.97, p = 0.011).",

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AU - Scholes, Sandra F E

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KW - Logistic Models

KW - Male

KW - Pancytopenia/etiology

KW - Pregnancy

KW - Retrospective Studies

KW - Risk Factors

KW - United Kingdom

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Factors associated with bovine neonatal pancytopenia (BNP) in calves: a case-control study

Abstract

Keywords

UN SDGs

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