Factors associated with bovine neonatal pancytopenia (BNP) in calves: a case-control study

Sarah L Lambton, Adrian D Colloff, Richard P Smith, George L Caldow, Sandra F E Scholes, Kim Willoughby, Fiona Howie, Johanne Ellis-Iversen, Graham David, Alasdair J C Cook, Andrew Holliman

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Bovine neonatal pancytopenia (BNP; previously known as idiopathic haemorrhagic diathesis and commonly known as bleeding calf syndrome) is a novel haemorrhagic disease of young calves which has emerged in a number of European countries during recent years. Data were retrospectively collected during June to November 2010 for 56 case calves diagnosed with BNP between 17 March and 7 June of the same year. These were compared with 58 control calves randomly recruited from herds with no history of BNP. Multivariable logistic regression analysis showed that increased odds of a calf being a BNP case were associated with its dam having received PregSure® BVD (Pfizer Animal Health) vaccination prior to the birth of the calf (odds ratio (OR) 40.78, p<0.001) and its herd of origin being located in Scotland (OR 9.71, p = 0.006). Decreased odds of a calf being a BNP case were associated with the calf having been kept outside (OR 0.11, p = 0.006). The longer that a cattle herd had been established on the farm was also associated with decreased odds of a calf in that herd being a BNP case (OR 0.97, p = 0.011).

Original languageEnglish
Article numbere34183
JournalPLoS ONE
Volume7
Issue number5
DOIs
Publication statusPrint publication - 11 May 2012

Keywords

  • Animals
  • Animals, Newborn
  • Case-Control Studies
  • Cattle
  • Cattle Diseases/etiology
  • Diarrhea Viruses, Bovine Viral/immunology
  • Female
  • Logistic Models
  • Male
  • Pancytopenia/etiology
  • Pregnancy
  • Retrospective Studies
  • Risk Factors
  • United Kingdom
  • Vaccination/adverse effects
  • Viral Vaccines/administration & dosage

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