Genetic dissection of complex behaviour traits in German Shepherd dogs

Juliane Friedrich, Erling Strandberg, Per Arvelius, Enrique Sánchez-Molano, Ricardo Pong-Wong, John Hickey, MJ Haskell, Pamela Wiener*

*Corresponding author for this work

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Abstract

A favourable genetic structure and diversity of behavioural features highlights the potential of dogs for studying the genetic architecture of behaviour traits. However, behaviours are complex traits, which have been shown to be influenced by numerous genetic and non-genetic factors, complicating their analysis. In this study, the genetic contribution to behaviour variation in German Shepherd dogs (GSDs) was analysed using genomic approaches. GSDs were phenotyped for behaviour traits using the established Canine Behavioral Assessment and Research Questionnaire (C-BARQ). Genome-wide association study (GWAS) and regional heritability mapping (RHM) approaches were employed to identify associations between behaviour traits and genetic variants, while accounting for relevant non-genetic factors. By combining these complementary methods we endeavoured to increase the power to detect loci with small effects. Several behavioural traits exhibited moderate heritabilities, with the highest identified for Human-directed playfulness, a trait characterised by positive interactions with humans. We identified several genomic regions associated with one or more of the analysed behaviour traits. Some candidate genes located in these regions were previously linked to behavioural disorders in humans, suggesting a new context for their influence on behaviour characteristics. Overall, the results support dogs as a valuable resource to dissect the genetic architecture of behaviour traits and also highlight the value of focusing on a single breed in order to control for background genetic effects and thus avoid limitations of between-breed analyses.
Original languageEnglish
Pages (from-to)746-758
Number of pages13
JournalHeredity
Volume123
Issue number6
DOIs
Publication statusPrint publication - 14 Oct 2019

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Dissection
Dogs
Behavioral Research
Genetic Structures
Genome-Wide Association Study
Canidae
Genes

Keywords

  • GWAS
  • Regional heritability mapping
  • C-BARQ

Cite this

Friedrich, J., Strandberg, E., Arvelius, P., Sánchez-Molano, E., Pong-Wong, R., Hickey, J., ... Wiener, P. (2019). Genetic dissection of complex behaviour traits in German Shepherd dogs. Heredity, 123(6), 746-758. https://doi.org/10.1038/s41437-019-0275-2
Friedrich, Juliane ; Strandberg, Erling ; Arvelius, Per ; Sánchez-Molano, Enrique ; Pong-Wong, Ricardo ; Hickey, John ; Haskell, MJ ; Wiener, Pamela. / Genetic dissection of complex behaviour traits in German Shepherd dogs. In: Heredity. 2019 ; Vol. 123, No. 6. pp. 746-758.
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Friedrich, J, Strandberg, E, Arvelius, P, Sánchez-Molano, E, Pong-Wong, R, Hickey, J, Haskell, MJ & Wiener, P 2019, 'Genetic dissection of complex behaviour traits in German Shepherd dogs', Heredity, vol. 123, no. 6, pp. 746-758. https://doi.org/10.1038/s41437-019-0275-2

Genetic dissection of complex behaviour traits in German Shepherd dogs. / Friedrich, Juliane; Strandberg, Erling; Arvelius, Per; Sánchez-Molano, Enrique; Pong-Wong, Ricardo; Hickey, John; Haskell, MJ; Wiener, Pamela.

In: Heredity, Vol. 123, No. 6, 14.10.2019, p. 746-758.

Research output: Contribution to journalArticle

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Friedrich J, Strandberg E, Arvelius P, Sánchez-Molano E, Pong-Wong R, Hickey J et al. Genetic dissection of complex behaviour traits in German Shepherd dogs. Heredity. 2019 Oct 14;123(6):746-758. https://doi.org/10.1038/s41437-019-0275-2