Genetic parameters of subclinical macromineral disorders and major clinical diseases in post parturient Holstein cows

V Tsiamadis, G Banos, N Panousis, M Kritsepi-Konstantinou, G Arsenos, GE Valergakis

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    Abstract

    The main objective of this study was to assess the genetic parameters of subclinical disorders associated with subclinical hypocalcemia, hypophosphatemia, subclinical hypomagnesemia, hypokalemia, and hyperphosphatemia, as well as major clinical diseases after calving in Holstein cows. The secondary objective was to estimate the associated genetic and phenotypic correlations among these subclinical and clinical conditions after calving in Holstein cows. The study was conducted in 9 dairy herds located in Northern Greece. None of the herds used any kind of preventive measures for milk fever (MF). A total of 1,021 Holstein cows with pedigree information were examined from November 2010 until November 2012. The distribution across parities was 466 (parity 1), 242 (parity 2), 165 (parity 3), and 148 (parity 4 and above) cows. All cows were subjected to a detailed clinical examination and blood was sampled on d 1, 2, 4, and 8 after calving. Serum concentrations of Ca, P, Mg, and K were measured in all samples, whereas β-hydroxybutyrate (BHB) was measured only for d 8. The final data set included 4,064 clinical and 16,848 biochemical records (4,020 Ca, 4,019 P, 4,020 Mg, 3,792 K, and 997 BHB). Data of 1,988 observations of body condition score at d 1 and 8 were also available. All health traits were analyzed with a univariate random regression model. The genetic analysis for macromineral-related disorders included 986 cows with no obvious signs of MF (35 cows with MF were excluded). Analysis for other health traits included all 1,021 cows. A similar single record model was used for the analysis of BHB. Genetic correlations among traits were estimated with a series of bivariate analyses. Statistically significant daily heritabilities of subclinical hypocalcemia (0.13–0.25), hypophosphatemia (0.18–0.33), subclinical hypomagnesemia (0.11–0.38), and hyperphosphatemia (0.14–0.22) were low to moderate, whereas that of hypokalemia was low (0.08–0.10). The heritability of body condition score was 0.20 ± 0.10. Statistically significant daily heritabilities of clinical diseases were those of MF (0.07–0.11), left displaced abomasum (0.19–0.31), and mastitis (0.15–0.41). Results suggest that these health disorders are heritable traits and could be minimized with proper genetic selection. Statistically significant phenotypic correlations were estimated for the first time between macromineral concentrations and almost all transition cow metabolic and infectious health disorders.
    Original languageEnglish
    Pages (from-to)4 - 7
    Number of pages4
    JournalJournal of Dairy Science
    Volume99
    Issue number11
    Early online date7 Sep 2016
    DOIs
    Publication statusFirst published - 7 Sep 2016

    Fingerprint

    Holstein
    cows
    milk fever
    parity (reproduction)
    hypomagnesemia
    hypokalemia
    calving
    heritability
    hypocalcemia
    phenotypic correlation
    genetic correlation
    body condition
    displaced abomasum
    blood serum
    dairy herds
    pedigree
    clinical examination
    Greece
    mastitis
    genetic techniques and protocols

    Bibliographical note

    1023517

    Keywords

    • Genetic parameters
    • Postpartum diseases
    • Subclinical macromineral disorders

    Cite this

    Tsiamadis, V ; Banos, G ; Panousis, N ; Kritsepi-Konstantinou, M ; Arsenos, G ; Valergakis, GE. / Genetic parameters of subclinical macromineral disorders and major clinical diseases in post parturient Holstein cows. In: Journal of Dairy Science. 2016 ; Vol. 99, No. 11. pp. 4 - 7.
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    Genetic parameters of subclinical macromineral disorders and major clinical diseases in post parturient Holstein cows. / Tsiamadis, V; Banos, G; Panousis, N; Kritsepi-Konstantinou, M; Arsenos, G; Valergakis, GE.

    In: Journal of Dairy Science, Vol. 99, No. 11, 07.09.2016, p. 4 - 7.

    Research output: Contribution to journalArticle

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    T1 - Genetic parameters of subclinical macromineral disorders and major clinical diseases in post parturient Holstein cows

    AU - Tsiamadis, V

    AU - Banos, G

    AU - Panousis, N

    AU - Kritsepi-Konstantinou, M

    AU - Arsenos, G

    AU - Valergakis, GE

    N1 - 1023517

    PY - 2016/9/7

    Y1 - 2016/9/7

    N2 - The main objective of this study was to assess the genetic parameters of subclinical disorders associated with subclinical hypocalcemia, hypophosphatemia, subclinical hypomagnesemia, hypokalemia, and hyperphosphatemia, as well as major clinical diseases after calving in Holstein cows. The secondary objective was to estimate the associated genetic and phenotypic correlations among these subclinical and clinical conditions after calving in Holstein cows. The study was conducted in 9 dairy herds located in Northern Greece. None of the herds used any kind of preventive measures for milk fever (MF). A total of 1,021 Holstein cows with pedigree information were examined from November 2010 until November 2012. The distribution across parities was 466 (parity 1), 242 (parity 2), 165 (parity 3), and 148 (parity 4 and above) cows. All cows were subjected to a detailed clinical examination and blood was sampled on d 1, 2, 4, and 8 after calving. Serum concentrations of Ca, P, Mg, and K were measured in all samples, whereas β-hydroxybutyrate (BHB) was measured only for d 8. The final data set included 4,064 clinical and 16,848 biochemical records (4,020 Ca, 4,019 P, 4,020 Mg, 3,792 K, and 997 BHB). Data of 1,988 observations of body condition score at d 1 and 8 were also available. All health traits were analyzed with a univariate random regression model. The genetic analysis for macromineral-related disorders included 986 cows with no obvious signs of MF (35 cows with MF were excluded). Analysis for other health traits included all 1,021 cows. A similar single record model was used for the analysis of BHB. Genetic correlations among traits were estimated with a series of bivariate analyses. Statistically significant daily heritabilities of subclinical hypocalcemia (0.13–0.25), hypophosphatemia (0.18–0.33), subclinical hypomagnesemia (0.11–0.38), and hyperphosphatemia (0.14–0.22) were low to moderate, whereas that of hypokalemia was low (0.08–0.10). The heritability of body condition score was 0.20 ± 0.10. Statistically significant daily heritabilities of clinical diseases were those of MF (0.07–0.11), left displaced abomasum (0.19–0.31), and mastitis (0.15–0.41). Results suggest that these health disorders are heritable traits and could be minimized with proper genetic selection. Statistically significant phenotypic correlations were estimated for the first time between macromineral concentrations and almost all transition cow metabolic and infectious health disorders.

    AB - The main objective of this study was to assess the genetic parameters of subclinical disorders associated with subclinical hypocalcemia, hypophosphatemia, subclinical hypomagnesemia, hypokalemia, and hyperphosphatemia, as well as major clinical diseases after calving in Holstein cows. The secondary objective was to estimate the associated genetic and phenotypic correlations among these subclinical and clinical conditions after calving in Holstein cows. The study was conducted in 9 dairy herds located in Northern Greece. None of the herds used any kind of preventive measures for milk fever (MF). A total of 1,021 Holstein cows with pedigree information were examined from November 2010 until November 2012. The distribution across parities was 466 (parity 1), 242 (parity 2), 165 (parity 3), and 148 (parity 4 and above) cows. All cows were subjected to a detailed clinical examination and blood was sampled on d 1, 2, 4, and 8 after calving. Serum concentrations of Ca, P, Mg, and K were measured in all samples, whereas β-hydroxybutyrate (BHB) was measured only for d 8. The final data set included 4,064 clinical and 16,848 biochemical records (4,020 Ca, 4,019 P, 4,020 Mg, 3,792 K, and 997 BHB). Data of 1,988 observations of body condition score at d 1 and 8 were also available. All health traits were analyzed with a univariate random regression model. The genetic analysis for macromineral-related disorders included 986 cows with no obvious signs of MF (35 cows with MF were excluded). Analysis for other health traits included all 1,021 cows. A similar single record model was used for the analysis of BHB. Genetic correlations among traits were estimated with a series of bivariate analyses. Statistically significant daily heritabilities of subclinical hypocalcemia (0.13–0.25), hypophosphatemia (0.18–0.33), subclinical hypomagnesemia (0.11–0.38), and hyperphosphatemia (0.14–0.22) were low to moderate, whereas that of hypokalemia was low (0.08–0.10). The heritability of body condition score was 0.20 ± 0.10. Statistically significant daily heritabilities of clinical diseases were those of MF (0.07–0.11), left displaced abomasum (0.19–0.31), and mastitis (0.15–0.41). Results suggest that these health disorders are heritable traits and could be minimized with proper genetic selection. Statistically significant phenotypic correlations were estimated for the first time between macromineral concentrations and almost all transition cow metabolic and infectious health disorders.

    KW - Genetic parameters

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    JF - Journal of Dairy Science

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