Genome sequence and analysis of the tuber crop potato

Potato Genome Sequencing Consortium

Research output: Contribution to journalArticle

1136 Citations (Scopus)

Abstract

Potato (Solanum tuberosum L.) is the world's most important non-grain food crop and is central to global food security. It is clonally propagated, highly heterozygous, autotetraploid, and suffers acute inbreeding depression. Here we use a homozygous doubled-monoploid potato clone to sequence and assemble 86% of the 844-megabase genome. We predict 39,031 protein-coding genes and present evidence for at least two genome duplication events indicative of a palaeopolyploid origin. As the first genome sequence of an asterid, the potato genome reveals 2,642 genes specific to this large angiosperm clade. We also sequenced a heterozygous diploid clone and show that gene presence/absence variants and other potentially deleterious mutations occur frequently and are a likely cause of inbreeding depression. Gene family expansion, tissue-specific expression and recruitment of genes to new pathways contributed to the evolution of tuber development. The potato genome sequence provides a platform for genetic improvement of this vital crop.

Original languageEnglish
Pages (from-to)189-95
Number of pages7
JournalNature
Volume475
Issue number7355
DOIs
Publication statusPrint publication - 10 Jul 2011
Externally publishedYes

Bibliographical note

©2011 Macmillan Publishers Limited. All rights reserved

Keywords

  • Evolution, Molecular
  • Gene Duplication
  • Gene Expression Regulation, Plant
  • Genes, Plant/genetics
  • Genetic Variation
  • Genome, Plant/genetics
  • Genomics
  • Haplotypes/genetics
  • Heterozygote
  • Homozygote
  • Immunity, Innate
  • Inbreeding
  • Molecular Sequence Annotation
  • Molecular Sequence Data
  • Plant Diseases/genetics
  • Ploidies
  • Solanum tuberosum/genetics

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  • Cite this

    Potato Genome Sequencing Consortium (2011). Genome sequence and analysis of the tuber crop potato. Nature, 475(7355), 189-95. https://doi.org/10.1038/nature10158