Genome-wide association studies of immune, disease and production traits in indigenous chicken ecotypes

A Psifidi, G Banos, O Matika, TT Desta, J Bettridge, DA Hume, T Dessie, R Christley, P Wigley, O Hanotte, P Kaiser

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42 Citations (Scopus)
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The majority of chickens in sub-Saharan Africa are indigenous ecotypes, well adapted to the local environment and raised in scavenging production systems. Although they are generally resilient to disease challenge, routine vaccination and biosecurity measures are rarely applied and infectious diseases remain a major cause of mortality and reduced productivity. Management and genetic improvement programmes are hampered by lack of routine data recording. Selective breeding based on genomic technologies may provide the means to enhance sustainability. In this study, we investigated the genetic architecture of antibody response to four major infectious diseases [infectious bursal disease (IBDV), Marek’s disease (MDV), fowl typhoid (SG), fowl cholera (PM)] and resistance to Eimeria and cestode parasitism, along with two production traits [body weight and body condition score (BCS)] in two distinct indigenous Ethiopian chicken ecotypes. We conducted variance component analyses, genome-wide association studies, and pathway and selective sweep analyses.
Original languageEnglish
JournalGenetics Selection Evolution
Issue number74
Early online date29 Sept 2016
Publication statusFirst published - 29 Sept 2016

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