Genome-wide association studies of immune, disease and production traits in indigenous chicken ecotypes

A Psifidi, G Banos, O Matika, TT Desta, J Bettridge, DA Hume, T Dessie, R Christley, P Wigley, O Hanotte, P Kaiser

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Abstract

The majority of chickens in sub-Saharan Africa are indigenous ecotypes, well adapted to the local environment and raised in scavenging production systems. Although they are generally resilient to disease challenge, routine vaccination and biosecurity measures are rarely applied and infectious diseases remain a major cause of mortality and reduced productivity. Management and genetic improvement programmes are hampered by lack of routine data recording. Selective breeding based on genomic technologies may provide the means to enhance sustainability. In this study, we investigated the genetic architecture of antibody response to four major infectious diseases [infectious bursal disease (IBDV), Marek’s disease (MDV), fowl typhoid (SG), fowl cholera (PM)] and resistance to Eimeria and cestode parasitism, along with two production traits [body weight and body condition score (BCS)] in two distinct indigenous Ethiopian chicken ecotypes. We conducted variance component analyses, genome-wide association studies, and pathway and selective sweep analyses.
Original languageEnglish
JournalGenetics Selection Evolution
Volume48
Issue number74
Early online date29 Sep 2016
DOIs
Publication statusFirst published - 29 Sep 2016

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ecotypes
infectious diseases
fowl typhoid
fowl cholera
chickens
infectious bursal disease
Marek disease
biosecurity
Eimeria
Sub-Saharan Africa
selection methods
Cestoda
genetic improvement
body condition
production technology
parasitism
vaccination
genomics
antibodies
body weight

Bibliographical note

1023517

Cite this

Psifidi, A ; Banos, G ; Matika, O ; Desta, TT ; Bettridge, J ; Hume, DA ; Dessie, T ; Christley, R ; Wigley, P ; Hanotte, O ; Kaiser, P. / Genome-wide association studies of immune, disease and production traits in indigenous chicken ecotypes. In: Genetics Selection Evolution. 2016 ; Vol. 48, No. 74.
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abstract = "The majority of chickens in sub-Saharan Africa are indigenous ecotypes, well adapted to the local environment and raised in scavenging production systems. Although they are generally resilient to disease challenge, routine vaccination and biosecurity measures are rarely applied and infectious diseases remain a major cause of mortality and reduced productivity. Management and genetic improvement programmes are hampered by lack of routine data recording. Selective breeding based on genomic technologies may provide the means to enhance sustainability. In this study, we investigated the genetic architecture of antibody response to four major infectious diseases [infectious bursal disease (IBDV), Marek’s disease (MDV), fowl typhoid (SG), fowl cholera (PM)] and resistance to Eimeria and cestode parasitism, along with two production traits [body weight and body condition score (BCS)] in two distinct indigenous Ethiopian chicken ecotypes. We conducted variance component analyses, genome-wide association studies, and pathway and selective sweep analyses.",
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Psifidi, A, Banos, G, Matika, O, Desta, TT, Bettridge, J, Hume, DA, Dessie, T, Christley, R, Wigley, P, Hanotte, O & Kaiser, P 2016, 'Genome-wide association studies of immune, disease and production traits in indigenous chicken ecotypes', Genetics Selection Evolution, vol. 48, no. 74. https://doi.org/10.1186/s12711-016-0252-7

Genome-wide association studies of immune, disease and production traits in indigenous chicken ecotypes. / Psifidi, A; Banos, G; Matika, O; Desta, TT; Bettridge, J; Hume, DA; Dessie, T; Christley, R; Wigley, P; Hanotte, O; Kaiser, P.

In: Genetics Selection Evolution, Vol. 48, No. 74, 29.09.2016.

Research output: Contribution to journalArticle

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T1 - Genome-wide association studies of immune, disease and production traits in indigenous chicken ecotypes

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AU - Banos, G

AU - Matika, O

AU - Desta, TT

AU - Bettridge, J

AU - Hume, DA

AU - Dessie, T

AU - Christley, R

AU - Wigley, P

AU - Hanotte, O

AU - Kaiser, P

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AB - The majority of chickens in sub-Saharan Africa are indigenous ecotypes, well adapted to the local environment and raised in scavenging production systems. Although they are generally resilient to disease challenge, routine vaccination and biosecurity measures are rarely applied and infectious diseases remain a major cause of mortality and reduced productivity. Management and genetic improvement programmes are hampered by lack of routine data recording. Selective breeding based on genomic technologies may provide the means to enhance sustainability. In this study, we investigated the genetic architecture of antibody response to four major infectious diseases [infectious bursal disease (IBDV), Marek’s disease (MDV), fowl typhoid (SG), fowl cholera (PM)] and resistance to Eimeria and cestode parasitism, along with two production traits [body weight and body condition score (BCS)] in two distinct indigenous Ethiopian chicken ecotypes. We conducted variance component analyses, genome-wide association studies, and pathway and selective sweep analyses.

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