Genomewide Linkage Study in 1,176 Affected Sister Pair Families Identifies a Significant Susceptibility Locus for Endometriosis on Chromosome 10q26

Susan A. Treloar, Jacqueline Wicks, Dale R. Nyholt, Grant W. Montgomery, Melanie Bahlo, Vicki Smith, Gary Dawson, Ian J. Mackay, Daniel E. Weeks, Simon T. Bennett, Alisoun Carey, Kelly R. Ewen-White, David L. Duffy, Daniel T. O’Connor, David H. Barlow, Nicholas G. Martin, Stephen H. Kennedy

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

Endometriosis is a common gynecological disease that affects up to 10% of women in their reproductive years. It causes pelvic pain, severe dysmenorrhea, and subfertility. The disease is defined as the presence of tissue resembling endometrium in sites outside the uterus. Its cause remains uncertain despite >50 years of hypothesis-driven research, and thus the therapeutic options are limited. Disease predisposition is inherited as a complex genetic trait, which provides an alternative route to understanding the disease. We seek to identify susceptibility loci, using a positional-cloning approach that starts with linkage analysis to identify genomic regions likely to harbor these genes. We conducted a linkage study of 1,176 families (931 from an Australian group and 245 from a U.K. group), each with at least two members-mainly affected sister pairs-with surgically diagnosed disease. We have identified a region of significant linkage on chromosome 10q26 (maximum LOD score [MLS] of 3.09; genomewide P = .047) and another region of suggestive linkage on chromosome 20p13 (MLS = 2.09). Minor peaks (with MLS > 1.0) were found on chromosomes 2, 6, 7, 8, 12, 14, 15, and 17. This is the first report of linkage to a major locus for endometriosis. The findings will facilitate discovery of novel positional genetic variants that influence the risk of developing this debilitating disease. Greater understanding of the aberrant cellular and molecular mechanisms involved in the etiology and pathophysiology of endometriosis should lead to better diagnostic methods and targeted treatments. © 2005 by The American Society of Human Genetics. All rights reserved.
Original languageEnglish
Pages (from-to)365-376
Number of pages12
JournalAmerican Journal of Human Genetics
Volume77
Issue number3
DOIs
Publication statusPrint publication - 4 Aug 2005
Externally publishedYes

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Endometriosis
Siblings
Chromosomes
Therapeutic Human Experimentation
Dysmenorrhea
Chromosomes, Human, Pair 6
Pelvic Pain
Chromosomes, Human, Pair 2
Endometrium
Infertility
Uterus
Organism Cloning
Genes

Cite this

Treloar, Susan A. ; Wicks, Jacqueline ; Nyholt, Dale R. ; Montgomery, Grant W. ; Bahlo, Melanie ; Smith, Vicki ; Dawson, Gary ; Mackay, Ian J. ; Weeks, Daniel E. ; Bennett, Simon T. ; Carey, Alisoun ; Ewen-White, Kelly R. ; Duffy, David L. ; O’Connor, Daniel T. ; Barlow, David H. ; Martin, Nicholas G. ; Kennedy, Stephen H. / Genomewide Linkage Study in 1,176 Affected Sister Pair Families Identifies a Significant Susceptibility Locus for Endometriosis on Chromosome 10q26. In: American Journal of Human Genetics. 2005 ; Vol. 77, No. 3. pp. 365-376.
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abstract = "Endometriosis is a common gynecological disease that affects up to 10{\%} of women in their reproductive years. It causes pelvic pain, severe dysmenorrhea, and subfertility. The disease is defined as the presence of tissue resembling endometrium in sites outside the uterus. Its cause remains uncertain despite >50 years of hypothesis-driven research, and thus the therapeutic options are limited. Disease predisposition is inherited as a complex genetic trait, which provides an alternative route to understanding the disease. We seek to identify susceptibility loci, using a positional-cloning approach that starts with linkage analysis to identify genomic regions likely to harbor these genes. We conducted a linkage study of 1,176 families (931 from an Australian group and 245 from a U.K. group), each with at least two members-mainly affected sister pairs-with surgically diagnosed disease. We have identified a region of significant linkage on chromosome 10q26 (maximum LOD score [MLS] of 3.09; genomewide P = .047) and another region of suggestive linkage on chromosome 20p13 (MLS = 2.09). Minor peaks (with MLS > 1.0) were found on chromosomes 2, 6, 7, 8, 12, 14, 15, and 17. This is the first report of linkage to a major locus for endometriosis. The findings will facilitate discovery of novel positional genetic variants that influence the risk of developing this debilitating disease. Greater understanding of the aberrant cellular and molecular mechanisms involved in the etiology and pathophysiology of endometriosis should lead to better diagnostic methods and targeted treatments. {\circledC} 2005 by The American Society of Human Genetics. All rights reserved.",
author = "Treloar, {Susan A.} and Jacqueline Wicks and Nyholt, {Dale R.} and Montgomery, {Grant W.} and Melanie Bahlo and Vicki Smith and Gary Dawson and Mackay, {Ian J.} and Weeks, {Daniel E.} and Bennett, {Simon T.} and Alisoun Carey and Ewen-White, {Kelly R.} and Duffy, {David L.} and O’Connor, {Daniel T.} and Barlow, {David H.} and Martin, {Nicholas G.} and Kennedy, {Stephen H.}",
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Treloar, SA, Wicks, J, Nyholt, DR, Montgomery, GW, Bahlo, M, Smith, V, Dawson, G, Mackay, IJ, Weeks, DE, Bennett, ST, Carey, A, Ewen-White, KR, Duffy, DL, O’Connor, DT, Barlow, DH, Martin, NG & Kennedy, SH 2005, 'Genomewide Linkage Study in 1,176 Affected Sister Pair Families Identifies a Significant Susceptibility Locus for Endometriosis on Chromosome 10q26', American Journal of Human Genetics, vol. 77, no. 3, pp. 365-376. https://doi.org/10.1086/432960

Genomewide Linkage Study in 1,176 Affected Sister Pair Families Identifies a Significant Susceptibility Locus for Endometriosis on Chromosome 10q26. / Treloar, Susan A.; Wicks, Jacqueline; Nyholt, Dale R.; Montgomery, Grant W.; Bahlo, Melanie; Smith, Vicki; Dawson, Gary; Mackay, Ian J.; Weeks, Daniel E.; Bennett, Simon T.; Carey, Alisoun; Ewen-White, Kelly R.; Duffy, David L.; O’Connor, Daniel T.; Barlow, David H.; Martin, Nicholas G.; Kennedy, Stephen H.

In: American Journal of Human Genetics, Vol. 77, No. 3, 04.08.2005, p. 365-376.

Research output: Contribution to journalArticle

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AU - Nyholt, Dale R.

AU - Montgomery, Grant W.

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AU - Dawson, Gary

AU - Mackay, Ian J.

AU - Weeks, Daniel E.

AU - Bennett, Simon T.

AU - Carey, Alisoun

AU - Ewen-White, Kelly R.

AU - Duffy, David L.

AU - O’Connor, Daniel T.

AU - Barlow, David H.

AU - Martin, Nicholas G.

AU - Kennedy, Stephen H.

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N2 - Endometriosis is a common gynecological disease that affects up to 10% of women in their reproductive years. It causes pelvic pain, severe dysmenorrhea, and subfertility. The disease is defined as the presence of tissue resembling endometrium in sites outside the uterus. Its cause remains uncertain despite >50 years of hypothesis-driven research, and thus the therapeutic options are limited. Disease predisposition is inherited as a complex genetic trait, which provides an alternative route to understanding the disease. We seek to identify susceptibility loci, using a positional-cloning approach that starts with linkage analysis to identify genomic regions likely to harbor these genes. We conducted a linkage study of 1,176 families (931 from an Australian group and 245 from a U.K. group), each with at least two members-mainly affected sister pairs-with surgically diagnosed disease. We have identified a region of significant linkage on chromosome 10q26 (maximum LOD score [MLS] of 3.09; genomewide P = .047) and another region of suggestive linkage on chromosome 20p13 (MLS = 2.09). Minor peaks (with MLS > 1.0) were found on chromosomes 2, 6, 7, 8, 12, 14, 15, and 17. This is the first report of linkage to a major locus for endometriosis. The findings will facilitate discovery of novel positional genetic variants that influence the risk of developing this debilitating disease. Greater understanding of the aberrant cellular and molecular mechanisms involved in the etiology and pathophysiology of endometriosis should lead to better diagnostic methods and targeted treatments. © 2005 by The American Society of Human Genetics. All rights reserved.

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