Green chemistry approaches for thiazole containing compounds as a potential scaffold for cancer therapy

The exhaustive exploration of the conventional synthetic approaches for the synthesis of nitrogen and sulphur containing heterocyclic moieties has diverted the attention of researchers towards novel eco-friendly strategies of these compounds. Several green chemistry-based synthetic methods like multi-component single pot reaction, recyclable green-based catalyst, green solvent, reusable solvent, ultrasound-mediated synthesis, the solvent-free and microwave-assisted technique have been developed for the synthesis of thiazole derivatives with anticancer potential. According to the cancer society, almost 14.1 million cancer cases and about 8.2 million deaths due to cancer have been reported, which implies that one of every seven deaths occurs due to cancer disease. The thiazole scaffold is contained in more than 18 FDA-approved drugs, as well as, in several experimental formulations. Among them, alpelisib, a thiazole-based drug with the brand name Pigray®, was approved in 2019 for the treatment of breast cancer. The goal of the present review is to highlight the recent advancements in the green chemistry-based synthesis of thiazole derivatives with the discussion of their structure-activity relationship. Based on innovative eco-friendly reports in synthetic literature, this paper compiled the green strategies-based development of thiazole derivatives from 2012 till now with effective anticancer potential.