Identification of G-protein-coupled receptors involved in inflammatory disease by genetic association studies

Roy Pettipher, Jon Mangion, Michael G. Hunter, Ian Mackay

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

G-protein-coupled receptors are not only highly tractable drug targets but also attractive candidates for genetic association studies because they are more polymorphic than most other classes of gene and these polymorphisms frequently lead to functional changes in the levels of expression or biological activity that can predispose to common diseases. A large-scale study to identify functional variants in G-protein-coupled receptors associated with inflammatory diseases has highlighted a spectrum of novel biological insights that range from identifying the involvement of orphan receptors in certain diseases through to highlighting new therapeutic indications for existing drugs. © 2005 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)412-417
Number of pages6
JournalCurrent Opinion in Pharmacology
Volume5
Issue number4
DOIs
Publication statusPrint publication - 2005
Externally publishedYes

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Genetic Association Studies
G-Protein-Coupled Receptors
Pharmaceutical Preparations
Genes
Therapeutics

Cite this

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abstract = "G-protein-coupled receptors are not only highly tractable drug targets but also attractive candidates for genetic association studies because they are more polymorphic than most other classes of gene and these polymorphisms frequently lead to functional changes in the levels of expression or biological activity that can predispose to common diseases. A large-scale study to identify functional variants in G-protein-coupled receptors associated with inflammatory diseases has highlighted a spectrum of novel biological insights that range from identifying the involvement of orphan receptors in certain diseases through to highlighting new therapeutic indications for existing drugs. {\circledC} 2005 Elsevier Ltd. All rights reserved.",
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Identification of G-protein-coupled receptors involved in inflammatory disease by genetic association studies. / Pettipher, Roy; Mangion, Jon; Hunter, Michael G.; Mackay, Ian.

In: Current Opinion in Pharmacology, Vol. 5, No. 4, 2005, p. 412-417.

Research output: Contribution to journalArticle

TY - JOUR

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AU - Pettipher, Roy

AU - Mangion, Jon

AU - Hunter, Michael G.

AU - Mackay, Ian

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AB - G-protein-coupled receptors are not only highly tractable drug targets but also attractive candidates for genetic association studies because they are more polymorphic than most other classes of gene and these polymorphisms frequently lead to functional changes in the levels of expression or biological activity that can predispose to common diseases. A large-scale study to identify functional variants in G-protein-coupled receptors associated with inflammatory diseases has highlighted a spectrum of novel biological insights that range from identifying the involvement of orphan receptors in certain diseases through to highlighting new therapeutic indications for existing drugs. © 2005 Elsevier Ltd. All rights reserved.

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