Interactive effects of protein nutrition, genetic growth potential and Heligmosomoides bakeri infection pressure on resilience and resistance in mice

JC Coltherd, SA Babayan, L Bunger, I Kyriazakis, JE Allen, JGM Houdijk

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

The ability of animals to cope with an increasing parasite load, in terms of resilience and resistance, may be affected by both nutrient supply and demand. Here, we hypothesized that host nutrition and growth potential interact and influence the ability of mice to cope with different parasite doses. Mice selected for high (ROH) or low (ROL) body weight were fed a low (40 g/kg; LP) or high (230 g/kg; HP) protein diet and infected with 0, 50, 100, 150, 200 or 250 L3 infective Heligmosomoides bakeri larvae. ROH-LP mice grew less at doses of 150 L3 and above, whilst growth of ROH-HP and of ROL mice was not affected by infection pressure. Total worm burdens reached a plateau at doses of 150L3, whilst ROH mice excreted fewer worm eggs than ROL mice. Serum antibodies increased with infection dose and ROH mice were found to have higher parasite-specific IgG1 titres than ROL mice. In contrast, ROL had higher total IgE titres than ROH mice, only on HP diets. The interaction between host nutrition and growth potential appears to differentially affect resilience and resistance in mice. However, the results support the view that parasitism penalises performance in animals selected for higher growth.
Original languageEnglish
Pages (from-to)1305 - 1315
Number of pages11
JournalParasitology
Volume138
Issue number10
Publication statusFirst published - 2011

Bibliographical note

66000009
66000013
66070007

Keywords

  • Growth potential
  • Heligmosomoides bakeri
  • Mice
  • Minimum level of parasitism
  • Protein nutrition
  • Resilience
  • Resistance
  • Serum antibody

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