Investigation of relationship between vitamin D status and reproductive fitness in Scottish hill sheep

PZ Zhou, TG McEvoy, Andrew C Gill, NR Lambe, C Morgan-Davies, Emma Hurst, ND Sargison, Richard J Mellanby

Research output: Contribution to journalArticleResearchpeer-review

Abstract

There is a growing interest in the influence of vitamin D on ovine non-skeletal health. The aim of this study was to explore the relationship between pre-mating vitamin D status, as assessed by serum concentrations of 25-Hydroxyvitamin D [25(OH)D; comprising D2 and D3] and subsequent reproductive performance of genetically unimproved Scottish Blackface (UBF), genetically improved Scottish Blackface (IBF) and Lleyn ewes kept under Scottish hill conditions. 25-Hydroxyvitamin D2 (25(OH)D2) and 25-Hydroxyvitamin D3 (25(OH)D3) concentrations were determined in serum samples harvested in November from ewes grazed outdoors. There were no significant differences in 25(OH)D2concentrations amongst the 3 genotypes. Lleyn ewes had significantly higher 25(OH)D3 and 25(OH)D concentrations than both Scottish Blackface ewe genotypes, whereas these vitamin D parameters did not differ significantly between the UBF and IBF ewes. Concentrations of 25(OH)D3 and 25(OH)D were positively associated with subsequent birth weights of singleton and of twin lamb litters. No significant associations between vitamin D status and number of lambs born or weaned per ewe were found. This study demonstrates that concentrations of cutaneously-derived 25(OH)D3, but not of orally consumed 25(OH)D2, differed between breeds. The positive association between ewe vitamin D status and offspring birth weight highlights the need for further investigations.
Original languageEnglish
Article number1162
JournalScientific Reports
Volume9
Early online date4 Feb 2019
DOIs
Publication statusPrint publication - 4 Feb 2019

Fingerprint

vitamin D
Scottish Blackface
ewes
25-hydroxycholecalciferol
sheep
birth weight
25-hydroxyergocalciferol
lambs
genotype
reproductive fitness
litters (young animals)
reproductive performance
breeds

Keywords

  • Agroecology
  • Agricultural genetics
  • Animal breeding

Cite this

@article{85eb0abdbcfa45a4b09eeed63c34397f,
title = "Investigation of relationship between vitamin D status and reproductive fitness in Scottish hill sheep",
abstract = "There is a growing interest in the influence of vitamin D on ovine non-skeletal health. The aim of this study was to explore the relationship between pre-mating vitamin D status, as assessed by serum concentrations of 25-Hydroxyvitamin D [25(OH)D; comprising D2 and D3] and subsequent reproductive performance of genetically unimproved Scottish Blackface (UBF), genetically improved Scottish Blackface (IBF) and Lleyn ewes kept under Scottish hill conditions. 25-Hydroxyvitamin D2 (25(OH)D2) and 25-Hydroxyvitamin D3 (25(OH)D3) concentrations were determined in serum samples harvested in November from ewes grazed outdoors. There were no significant differences in 25(OH)D2concentrations amongst the 3 genotypes. Lleyn ewes had significantly higher 25(OH)D3 and 25(OH)D concentrations than both Scottish Blackface ewe genotypes, whereas these vitamin D parameters did not differ significantly between the UBF and IBF ewes. Concentrations of 25(OH)D3 and 25(OH)D were positively associated with subsequent birth weights of singleton and of twin lamb litters. No significant associations between vitamin D status and number of lambs born or weaned per ewe were found. This study demonstrates that concentrations of cutaneously-derived 25(OH)D3, but not of orally consumed 25(OH)D2, differed between breeds. The positive association between ewe vitamin D status and offspring birth weight highlights the need for further investigations.",
keywords = "Agroecology, Agricultural genetics, Animal breeding",
author = "PZ Zhou and TG McEvoy and Gill, {Andrew C} and NR Lambe and C Morgan-Davies and Emma Hurst and ND Sargison and Mellanby, {Richard J}",
year = "2019",
month = "2",
day = "4",
doi = "10.1038/s41598-018-37843-6",
language = "English",
volume = "9",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Research",

}

Investigation of relationship between vitamin D status and reproductive fitness in Scottish hill sheep. / Zhou, PZ; McEvoy, TG; Gill, Andrew C; Lambe, NR; Morgan-Davies, C; Hurst, Emma; Sargison, ND; Mellanby, Richard J.

In: Scientific Reports, Vol. 9, 1162, 04.02.2019.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Investigation of relationship between vitamin D status and reproductive fitness in Scottish hill sheep

AU - Zhou, PZ

AU - McEvoy, TG

AU - Gill, Andrew C

AU - Lambe, NR

AU - Morgan-Davies, C

AU - Hurst, Emma

AU - Sargison, ND

AU - Mellanby, Richard J

PY - 2019/2/4

Y1 - 2019/2/4

N2 - There is a growing interest in the influence of vitamin D on ovine non-skeletal health. The aim of this study was to explore the relationship between pre-mating vitamin D status, as assessed by serum concentrations of 25-Hydroxyvitamin D [25(OH)D; comprising D2 and D3] and subsequent reproductive performance of genetically unimproved Scottish Blackface (UBF), genetically improved Scottish Blackface (IBF) and Lleyn ewes kept under Scottish hill conditions. 25-Hydroxyvitamin D2 (25(OH)D2) and 25-Hydroxyvitamin D3 (25(OH)D3) concentrations were determined in serum samples harvested in November from ewes grazed outdoors. There were no significant differences in 25(OH)D2concentrations amongst the 3 genotypes. Lleyn ewes had significantly higher 25(OH)D3 and 25(OH)D concentrations than both Scottish Blackface ewe genotypes, whereas these vitamin D parameters did not differ significantly between the UBF and IBF ewes. Concentrations of 25(OH)D3 and 25(OH)D were positively associated with subsequent birth weights of singleton and of twin lamb litters. No significant associations between vitamin D status and number of lambs born or weaned per ewe were found. This study demonstrates that concentrations of cutaneously-derived 25(OH)D3, but not of orally consumed 25(OH)D2, differed between breeds. The positive association between ewe vitamin D status and offspring birth weight highlights the need for further investigations.

AB - There is a growing interest in the influence of vitamin D on ovine non-skeletal health. The aim of this study was to explore the relationship between pre-mating vitamin D status, as assessed by serum concentrations of 25-Hydroxyvitamin D [25(OH)D; comprising D2 and D3] and subsequent reproductive performance of genetically unimproved Scottish Blackface (UBF), genetically improved Scottish Blackface (IBF) and Lleyn ewes kept under Scottish hill conditions. 25-Hydroxyvitamin D2 (25(OH)D2) and 25-Hydroxyvitamin D3 (25(OH)D3) concentrations were determined in serum samples harvested in November from ewes grazed outdoors. There were no significant differences in 25(OH)D2concentrations amongst the 3 genotypes. Lleyn ewes had significantly higher 25(OH)D3 and 25(OH)D concentrations than both Scottish Blackface ewe genotypes, whereas these vitamin D parameters did not differ significantly between the UBF and IBF ewes. Concentrations of 25(OH)D3 and 25(OH)D were positively associated with subsequent birth weights of singleton and of twin lamb litters. No significant associations between vitamin D status and number of lambs born or weaned per ewe were found. This study demonstrates that concentrations of cutaneously-derived 25(OH)D3, but not of orally consumed 25(OH)D2, differed between breeds. The positive association between ewe vitamin D status and offspring birth weight highlights the need for further investigations.

KW - Agroecology

KW - Agricultural genetics

KW - Animal breeding

U2 - 10.1038/s41598-018-37843-6

DO - 10.1038/s41598-018-37843-6

M3 - Article

VL - 9

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 1162

ER -