Limits to sustained energy intake. XXII. Reproductive performance of two selected mouse lines with different thermal conductance

AH Al Jothery, E Krol, J Hawkins, A Chetoui, A Saint-Lambert, Y Gamo, SC Shaw, T Valencak, L Bunger, WG Hill, LM Vaanholt, C Hambly, JR Speakman

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Abstract

Maximal sustained energy intake (SusEI) appears limited, but the factors imposing the limit are disputed. We studied reproductive performance in two lines of mice selected for high and low food intake (MH and ML, respectively), and known to have large differences in thermal conductance (29% higher in the MH line at 21°C). When these mice raised their natural litters, their metabolisable energy intake significantly increased over the first 13 days of lactation and then reached a plateau. At peak lactation, MH mice assimilated on average 45.3% more energy than ML mice (222.9±7.1 and 153.4±12.5 kJ day(-1), N=49 and 24, respectively). Moreover, MH mice exported on average 62.3 kJ day(-1) more energy as milk than ML mice (118.9±5.3 and 56.6±5.4 kJ day(-1), N=subset of 32 and 21, respectively). The elevated milk production of MH mice enabled them to wean litters (65.2±2.1 g) that were on average 50.2% heavier than litters produced by ML mothers (43.4±3.0 g), and pups that were on average 27.2% heavier (9.9±0.2 and 7.8±0.2 g, respectively). Lactating mice in both lines had significantly longer and heavier guts compared with non-reproductive mice. However, inconsistent with the 'central limit hypothesis', the ML mice had significantly longer and heavier intestines than MH mice. An experiment where the mice raised litters of the opposing line demonstrated that lactation performance was not limited by the growth capacity of offspring. Our findings are consistent with the idea that the SusEI at peak lactation is constrained by the capacity of the mothers to dissipate body heat.
Original languageEnglish
Pages (from-to)3718 - 3732
Number of pages15
JournalJournal of Experimental Biology
Volume217
DOIs
Publication statusPrint publication - 2014

Fingerprint

thermal conductivity
reproductive performance
energy intake
mice
litters (young animals)
lactation
energy
metabolizable energy
pups
food intake
milk production
plateaus
intestines
digestive system

Bibliographical note

1023378

Keywords

  • Artificial selection
  • Cross-fostering
  • Daily energy expenditure
  • Heat dissipation limit
  • Lactation
  • Milk production

Cite this

Al Jothery, AH., Krol, E., Hawkins, J., Chetoui, A., Saint-Lambert, A., Gamo, Y., ... Speakman, JR. (2014). Limits to sustained energy intake. XXII. Reproductive performance of two selected mouse lines with different thermal conductance. Journal of Experimental Biology, 217, 3718 - 3732. https://doi.org/10.1242/jeb.103705
Al Jothery, AH ; Krol, E ; Hawkins, J ; Chetoui, A ; Saint-Lambert, A ; Gamo, Y ; Shaw, SC ; Valencak, T ; Bunger, L ; Hill, WG ; Vaanholt, LM ; Hambly, C ; Speakman, JR. / Limits to sustained energy intake. XXII. Reproductive performance of two selected mouse lines with different thermal conductance. In: Journal of Experimental Biology. 2014 ; Vol. 217. pp. 3718 - 3732.
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Al Jothery, AH, Krol, E, Hawkins, J, Chetoui, A, Saint-Lambert, A, Gamo, Y, Shaw, SC, Valencak, T, Bunger, L, Hill, WG, Vaanholt, LM, Hambly, C & Speakman, JR 2014, 'Limits to sustained energy intake. XXII. Reproductive performance of two selected mouse lines with different thermal conductance', Journal of Experimental Biology, vol. 217, pp. 3718 - 3732. https://doi.org/10.1242/jeb.103705

Limits to sustained energy intake. XXII. Reproductive performance of two selected mouse lines with different thermal conductance. / Al Jothery, AH; Krol, E; Hawkins, J; Chetoui, A; Saint-Lambert, A; Gamo, Y; Shaw, SC; Valencak, T; Bunger, L; Hill, WG; Vaanholt, LM; Hambly, C; Speakman, JR.

In: Journal of Experimental Biology, Vol. 217, 2014, p. 3718 - 3732.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Limits to sustained energy intake. XXII. Reproductive performance of two selected mouse lines with different thermal conductance

AU - Al Jothery, AH

AU - Krol, E

AU - Hawkins, J

AU - Chetoui, A

AU - Saint-Lambert, A

AU - Gamo, Y

AU - Shaw, SC

AU - Valencak, T

AU - Bunger, L

AU - Hill, WG

AU - Vaanholt, LM

AU - Hambly, C

AU - Speakman, JR

N1 - 1023378

PY - 2014

Y1 - 2014

N2 - Maximal sustained energy intake (SusEI) appears limited, but the factors imposing the limit are disputed. We studied reproductive performance in two lines of mice selected for high and low food intake (MH and ML, respectively), and known to have large differences in thermal conductance (29% higher in the MH line at 21°C). When these mice raised their natural litters, their metabolisable energy intake significantly increased over the first 13 days of lactation and then reached a plateau. At peak lactation, MH mice assimilated on average 45.3% more energy than ML mice (222.9±7.1 and 153.4±12.5 kJ day(-1), N=49 and 24, respectively). Moreover, MH mice exported on average 62.3 kJ day(-1) more energy as milk than ML mice (118.9±5.3 and 56.6±5.4 kJ day(-1), N=subset of 32 and 21, respectively). The elevated milk production of MH mice enabled them to wean litters (65.2±2.1 g) that were on average 50.2% heavier than litters produced by ML mothers (43.4±3.0 g), and pups that were on average 27.2% heavier (9.9±0.2 and 7.8±0.2 g, respectively). Lactating mice in both lines had significantly longer and heavier guts compared with non-reproductive mice. However, inconsistent with the 'central limit hypothesis', the ML mice had significantly longer and heavier intestines than MH mice. An experiment where the mice raised litters of the opposing line demonstrated that lactation performance was not limited by the growth capacity of offspring. Our findings are consistent with the idea that the SusEI at peak lactation is constrained by the capacity of the mothers to dissipate body heat.

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KW - Artificial selection

KW - Cross-fostering

KW - Daily energy expenditure

KW - Heat dissipation limit

KW - Lactation

KW - Milk production

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DO - 10.1242/jeb.103705

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