Linkage disequilibrium in young genetically isolated Dutch population

Yurii S. Aulchenko, Peter Heutink, Ian Mackay, Aida M. Bertoli-Avella, Jan Pullen, Norbert Vaessen, Tessa A.M. Rademaker, Lodewijk A. Sankuijl, Lon Cardon, Ben Oostra, Cornelia M. van Duijn

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Abstract

The design and feasibility of genetic studies of complex diseases are critically dependent on the extent and distribution of linkage disequilibrium (LD) across the genome and between different populations. We have examined genomewide and region-specific LD in a young genetically isolated population identified in the Netherlands by genotyping approximately 800 Short Tandem Repeat markers distributed genomewide across 58 individuals. Several regions were analyzed further using a denser marker map. The permutation-corrected measure of LD was used for analysis. A significant (P
Original languageEnglish
Pages (from-to)527-534
Number of pages8
JournalEuropean Journal of Human Genetics
Volume12
Issue number7
DOIs
Publication statusPrint publication - Jul 2004
Externally publishedYes

Keywords

  • Europe
  • Genetic isolation
  • Linkage disequilibrium
  • Population
  • Simulation

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  • Cite this

    Aulchenko, Y. S., Heutink, P., Mackay, I., Bertoli-Avella, A. M., Pullen, J., Vaessen, N., Rademaker, T. A. M., Sankuijl, L. A., Cardon, L., Oostra, B., & van Duijn, C. M. (2004). Linkage disequilibrium in young genetically isolated Dutch population. European Journal of Human Genetics, 12(7), 527-534. https://doi.org/10.1038/sj.ejhg.5201188