Abstract
The design and feasibility of genetic studies of complex diseases are critically dependent on the extent and distribution of linkage disequilibrium (LD) across the genome and between different populations. We have examined genomewide and region-specific LD in a young genetically isolated population identified in the Netherlands by genotyping approximately 800 Short Tandem Repeat markers distributed genomewide across 58 individuals. Several regions were analyzed further using a denser marker map. The permutation-corrected measure of LD was used for analysis. A significant (P
Original language | English |
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Pages (from-to) | 527-534 |
Number of pages | 8 |
Journal | European Journal of Human Genetics |
Volume | 12 |
Issue number | 7 |
DOIs | |
Publication status | Print publication - Jul 2004 |
Externally published | Yes |
Keywords
- Europe
- Genetic isolation
- Linkage disequilibrium
- Population
- Simulation