Major Histocompatilibility Complex (MHC) class II sequence polymorphism in long-finned pilot whale (Globicephala melas) from the North Atlantic

SS Monteiro, JV Vingada, A Lopez, GJ Pierce, M Ferreira, A Brownlow, B Mikkelsen, M Niemeyer, RJ Deaville, C Eira, S Piertney

Research output: Contribution to journalArticle

Abstract

Determining how intra-specific genetic diversity is apportioned among natural populations is essential for detecting local adaptation and identifying populations with inherently low levels of extant diversity which may become a conservation concern. Sequence polymorphism at two adaptive loci (MHC DRA and DQB) was investigated in long-finned pilot whales (Globicephala melas) from four regions in the North Atlantic and compared with previous data from New Zealand (South Pacific). Three alleles were resolved at each locus, with trans-species allele sharing and higher levels of non-synonymous to synonymous substitution, especially in the DQB locus. Overall nucleotide diversities of 0.49 ± 0.38% and 4.60 ± 2.39% were identified for the DRA and DQB loci, respectively, which are relatively low for MHC loci in the North Atlantic, but comparable to levels previously described in New Zealand (South Pacific). There were significant differences in allele frequencies within the North Atlantic and between the North Atlantic and New Zealand. Patterns of diversity and divergence are consistent with the long-term effects of balancing selection operating on the MHC loci, potentially mediated through the effects of host-parasite coevolution. Differences in allele frequency may reflect variation in pathogen communities, coupled with the effects of differential drift and gene flow.
Original languageEnglish
Pages (from-to)595 - 607
Number of pages13
JournalMarine Biology Research
Volume12
Issue number6
DOIs
Publication statusFirst published - 15 Jun 2016

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whales
genetic polymorphism
loci
gene frequency
alleles
coevolution
long term effects
gene flow
nucleotides
parasites
genetic variation
pathogens

Cite this

Monteiro, SS ; Vingada, JV ; Lopez, A ; Pierce, GJ ; Ferreira, M ; Brownlow, A ; Mikkelsen, B ; Niemeyer, M ; Deaville, RJ ; Eira, C ; Piertney, S. / Major Histocompatilibility Complex (MHC) class II sequence polymorphism in long-finned pilot whale (Globicephala melas) from the North Atlantic. In: Marine Biology Research. 2016 ; Vol. 12, No. 6. pp. 595 - 607.
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abstract = "Determining how intra-specific genetic diversity is apportioned among natural populations is essential for detecting local adaptation and identifying populations with inherently low levels of extant diversity which may become a conservation concern. Sequence polymorphism at two adaptive loci (MHC DRA and DQB) was investigated in long-finned pilot whales (Globicephala melas) from four regions in the North Atlantic and compared with previous data from New Zealand (South Pacific). Three alleles were resolved at each locus, with trans-species allele sharing and higher levels of non-synonymous to synonymous substitution, especially in the DQB locus. Overall nucleotide diversities of 0.49 ± 0.38{\%} and 4.60 ± 2.39{\%} were identified for the DRA and DQB loci, respectively, which are relatively low for MHC loci in the North Atlantic, but comparable to levels previously described in New Zealand (South Pacific). There were significant differences in allele frequencies within the North Atlantic and between the North Atlantic and New Zealand. Patterns of diversity and divergence are consistent with the long-term effects of balancing selection operating on the MHC loci, potentially mediated through the effects of host-parasite coevolution. Differences in allele frequency may reflect variation in pathogen communities, coupled with the effects of differential drift and gene flow.",
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Monteiro, SS, Vingada, JV, Lopez, A, Pierce, GJ, Ferreira, M, Brownlow, A, Mikkelsen, B, Niemeyer, M, Deaville, RJ, Eira, C & Piertney, S 2016, 'Major Histocompatilibility Complex (MHC) class II sequence polymorphism in long-finned pilot whale (Globicephala melas) from the North Atlantic', Marine Biology Research, vol. 12, no. 6, pp. 595 - 607. https://doi.org/10.1080/17451000.2016.1174266

Major Histocompatilibility Complex (MHC) class II sequence polymorphism in long-finned pilot whale (Globicephala melas) from the North Atlantic. / Monteiro, SS; Vingada, JV; Lopez, A; Pierce, GJ; Ferreira, M; Brownlow, A; Mikkelsen, B; Niemeyer, M; Deaville, RJ; Eira, C; Piertney, S.

In: Marine Biology Research, Vol. 12, No. 6, 15.06.2016, p. 595 - 607.

Research output: Contribution to journalArticle

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AU - Monteiro, SS

AU - Vingada, JV

AU - Lopez, A

AU - Pierce, GJ

AU - Ferreira, M

AU - Brownlow, A

AU - Mikkelsen, B

AU - Niemeyer, M

AU - Deaville, RJ

AU - Eira, C

AU - Piertney, S

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AB - Determining how intra-specific genetic diversity is apportioned among natural populations is essential for detecting local adaptation and identifying populations with inherently low levels of extant diversity which may become a conservation concern. Sequence polymorphism at two adaptive loci (MHC DRA and DQB) was investigated in long-finned pilot whales (Globicephala melas) from four regions in the North Atlantic and compared with previous data from New Zealand (South Pacific). Three alleles were resolved at each locus, with trans-species allele sharing and higher levels of non-synonymous to synonymous substitution, especially in the DQB locus. Overall nucleotide diversities of 0.49 ± 0.38% and 4.60 ± 2.39% were identified for the DRA and DQB loci, respectively, which are relatively low for MHC loci in the North Atlantic, but comparable to levels previously described in New Zealand (South Pacific). There were significant differences in allele frequencies within the North Atlantic and between the North Atlantic and New Zealand. Patterns of diversity and divergence are consistent with the long-term effects of balancing selection operating on the MHC loci, potentially mediated through the effects of host-parasite coevolution. Differences in allele frequency may reflect variation in pathogen communities, coupled with the effects of differential drift and gene flow.

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JO - Marine Biology Research

JF - Marine Biology Research

SN - 1745-1000

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ER -