Metabolomics-Driven Mining of Metabolite Resources: Applications and Prospects for Improving Vegetable Crops

Dhananjaya Pratap Singh*, Mansi Singh Bisen, Renu Shukla, Ratna Prabha, Sudarshan Maurya, Yesaru S. Reddy, Prabhakar Mohan Singh, Nagendra Rai, Tribhuwan Chaubey, Krishna Kumar Chaturvedi, Sudhir Srivastava, Mohammad Samir Farooqi, Vijai Kumar Gupta, Birinchi K. Sarma, Anil Rai, Tusar Kanti Behera

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)
19 Downloads (Pure)

Abstract

Vegetable crops possess a prominent nutri-metabolite pool that not only contributes to the crop performance in the fields, but also offers nutritional security for humans. In the pursuit of identifying, quantifying and functionally characterizing the cellular metabolome pool, biomolecule separation technologies, data acquisition platforms, chemical libraries, bioinformatics tools, databases and visualization techniques have come to play significant role. High-throughput metabolomics unravels structurally diverse nutrition-rich metabolites and their entangled interactions in vegetable plants. It has helped to link identified phytometabolites with unique phenotypic traits, nutri-functional characters, defense mechanisms and crop productivity. In this study, we explore mining diverse metabolites, localizing cellular metabolic pathways, classifying functional biomolecules and establishing linkages between metabolic fluxes and genomic regulations, using comprehensive metabolomics deciphers of the plant’s performance in the environment. We discuss exemplary reports covering the implications of metabolomics, addressing metabolic changes in vegetable plants during crop domestication, stage-dependent growth, fruit development, nutri-metabolic capabilities, climatic impacts, plant-microbe-pest interactions and anthropogenic activities. Efforts leading to identify biomarker metabolites, candidate proteins and the genes responsible for plant health, defense mechanisms and nutri-rich crop produce are documented. With the insights on metabolite-QTL (mQTL) driven genetic architecture, molecular breeding in vegetable crops can be revolutionized for developing better nutritional capabilities, improved tolerance against diseases/pests and enhanced climate resilience in plants.

Original languageEnglish
Article number12062
JournalInternational Journal of Molecular Sciences
Volume23
Issue number20
Early online date11 Oct 2022
DOIs
Publication statusFirst published - 11 Oct 2022

Keywords

  • crop improvement
  • mass spectrometry
  • metabolite analysis
  • metabolites
  • metabolome
  • metabolomics
  • NMR
  • vegetables
  • Vegetables
  • Humans
  • Small Molecule Libraries
  • Biomarkers
  • Crops, Agricultural/genetics
  • Metabolomics/methods

Fingerprint

Dive into the research topics of 'Metabolomics-Driven Mining of Metabolite Resources: Applications and Prospects for Improving Vegetable Crops'. Together they form a unique fingerprint.

Cite this