Methods of preparation of metal-doped and hybrid tungsten oxide nanoparticles for anticancer, antibacterial, and biosensing applications

Anirudh Sharma, Adesh K. Saini, Nitin Kumar, Neeraj Tejwan, Th Abhishek Singh, Vijay Kumar Thakur, Joydeep Das*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)
165 Downloads (Pure)


Tungsten oxide (WOx) is one of the most important and commonly used n-type wide band-gap oxygen-deficient metal oxide semiconductors with several important physicochemical properties, which enabled them to be used in numerous biomedical applications. Recently, researchers have demonstrated that: (I) suitable modifications in their dimension, crystal structure and morphology by doping metals into the WOx lattice framework play a critical role in improving their applications by tuning the physicochemical properties; (ii) metal doped WOx nanoparticles (NPs) can generate reactive oxygen species (ROS) upon absorption of NIR light even in the absence of photosensitizer and molecular oxygen; (iii) doping of noble metals into WOx films increase their electrical conductivity for improved electrochemical sensing; and (iv) the binary and ternary conjugates of WOx or tungsten-bronze exhibit increased photoelectric conversion ability and ROS production rate as well as improved photothermal conversion efficiency. However, no comprehensive review article has been reported yet on metal-doped WOxNPs and hybrid WOx nanocomposites. Therefore, herein we aimed to discuss firstly the several methods of metal-doped and hybrid WOxNPs synthesis such as precipitation, hydrothermal, microwave and solvothermal methods, etc. with appropriate conditions that control their size, shape, crystal structure and defects upon which the physicochemical properties depend. After that, we have discussed about some of their important physicochemical properties. Finally, we thoroughly reviewed the biomedical applications of WOxNPs in the field of biosensing, imaging, antibacterial and anticancer therapy with probable mechanisms. Finally, we have discussed the lacunae and the anticipated applications of WOxNPs. This review will provide a platform for understanding the different synthesis routes and the mechanistic details of the biomedical applications of metal-doped/hybrid WOxNPs to design novel nanocomposites with improved physico-chemical properties for their future applications.

Original languageEnglish
Article number101641
JournalSurfaces and Interfaces
Early online date28 Nov 2021
Publication statusPrint publication - Feb 2022

Bibliographical note

Publisher Copyright:
© 2021 Elsevier B.V.


  • Antibacterial
  • Anticancer
  • Sensing
  • Synthesis
  • Tungsten oxide


Dive into the research topics of 'Methods of preparation of metal-doped and hybrid tungsten oxide nanoparticles for anticancer, antibacterial, and biosensing applications'. Together they form a unique fingerprint.

Cite this