Microbial cancer therapeutics: A promising approach

Deepti Diwan, Lei Cheng, Zeba Usmani, Minaxi Sharma, Nicola Holden, Nicholas Willoughby, Neelam Sangwan, Rama Raju Baadhe, Chenchen Liu*, Vijai Kumar Gupta*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The success of conventional cancer therapeutics is hindered by associated dreadful side-effects of antibiotic resistance and the dearth of antitumor drugs' selectivity and specificity. Hence, the conceptual evolution of anti-cancerous therapeutic agents that selectively target cancer cells without impacting the healthy cells or tissues, has led to a new wave of scientific interest in microbial-derived bioactive molecules. Such strategic solutions may pave the way to surmount the shortcomings of conventional therapies and raise the potential and hope for the cure of wide range of cancer in a selective manner. This review aims to provide a comprehensive summary of anti-carcinogenic properties and underlying mechanisms of bioactive molecules of microbial origin, and discuss the current challenges and effective therapeutic application of combinatorial strategies to attain minimal systemic side-effects.

Original languageEnglish
JournalSeminars in Cancer Biology
Early online date9 May 2021
DOIs
Publication statusFirst published - 9 May 2021

Keywords

  • Bacteriocins
  • Bioactive molecules
  • Cancer
  • Genetically engineered microbes
  • Microbial therapy

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