Mitochondrial DNA variation reveals maternal origins and demographic dynamics of Ethiopian indigenous goats

Getinet Mekuriaw Tarekegn*, Kassahun Tesfaye, Okeyo Ally Mwai, Appolinaire Djikeng, Tadelle Dessie, Josephine Birungi, Sarah Osama, Netsanet Zergaw, Alubel Alemu, Gloria Achieng, Jack Tutah, Collins Mutai, Joyce Njuguna, Joram M. Mwacharo

*Corresponding author for this work

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The Horn of Africa forms one of the two main historical entry points of domestics into the continent and Ethiopia is particularly important in this regard. Through the analysis of mitochondrial DNA (mtDNA) d-loop region in 309 individuals from 13 populations, we reveal the maternal genetic variation and demographic dynamics of Ethiopian indigenous goats. A total of 174 variable sites that generated 231 haplotypes were observed. They defined two haplogroups that were present in all the 13 study populations. Reference haplotypes from the six globally defined goat mtDNA haplogroups show the two haplogroups present in Ethiopia to be A and G, the former being the most predominant. Although both haplogroups are characterized by an increase in effective population sizes (Ne) predating domestication, they also have experienced a decline in Ne at different time periods, suggesting different demographic histories. We observed seven haplotypes, six were directly linked to the central haplotypes of the two haplogroups and one was central to haplogroup G. The seven haplotypes were common between Ethiopia, Kenya, Egypt, and Saudi Arabia populations, suggesting common maternal history and the introduction of goats into East Africa via Egypt and the Arabian Peninsula, respectively. While providing new mtDNA data from a historically important region, our results suggest extensive intermixing of goats mediated by human socio-cultural and economic interactions. These have led to the coexistence of the two haplogroups in different geographic regions in Ethiopia resulting in a large caprine genetic diversity that can be exploited for genetic improvement.

Original languageEnglish
Pages (from-to)1543-1553
Number of pages11
JournalEcology and Evolution
Volume8
Issue number3
Early online date3 Jan 2018
DOIs
Publication statusPrint publication - 1 Feb 2018
Externally publishedYes

Keywords

  • Bayesian skyline plot
  • genetic diversity
  • haplogroups
  • haplotypes
  • population expansion

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    Tarekegn, G. M., Tesfaye, K., Mwai, O. A., Djikeng, A., Dessie, T., Birungi, J., Osama, S., Zergaw, N., Alemu, A., Achieng, G., Tutah, J., Mutai, C., Njuguna, J., & Mwacharo, J. M. (2018). Mitochondrial DNA variation reveals maternal origins and demographic dynamics of Ethiopian indigenous goats. Ecology and Evolution, 8(3), 1543-1553. https://doi.org/10.1002/ece3.3710