Molecular Interaction of Bone Marrow Adipose Tissue with Energy Metabolism

Karla J. Suchacki*, William P. Cawthorn

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


The last decade has seen a resurgence in the study of bone marrow adipose tissue (BMAT) across diverse fields such as metabolism, haematopoiesis, skeletal biology and cancer. Herein, we review the most recent developments of BMAT research in both humans and rodents, including the distinct nature of BMAT; the autocrine, paracrine and endocrine interactions between BMAT and various tissues, both in physiological and pathological scenarios; how these interactions might impact energy metabolism; and the most recent technological advances to quantify BMAT. Though still dwarfed by research into white and brown adipose tissues, BMAT is now recognised as endocrine organ and is attracting increasing attention from biomedical researchers around the globe. We are beginning to learn the importance of BMAT both within and beyond the bone, allowing us to better appreciate the role of BMAT in normal physiology and disease.
Original languageEnglish
Pages (from-to)41-49
Number of pages9
JournalMolecular Biology Reports
Issue number2
Publication statusPrint publication - Jun 2018
Externally publishedYes


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