Multifunctional polymeric nanoplatforms for brain diseases diagnosis, therapy and theranostics

Shahryar Shakeri, Milad Ashrafizadeh, Ali Zarrabi, Rasoul Roghanian, Elham Ghasemipour Afshar, Abbas Pardakhty, Reza Mohammadinejad*, Anuj Kumar, Vijay Kumar Thakur

*Corresponding author for this work

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

The blood-brain barrier (BBB) acts as a barrier to prevent the central nervous system (CNS) from damage by substances that originate from the blood circulation. The BBB limits drug penetration into the brain and is one of the major clinical obstacles to the treatment of CNS diseases. Nanotechnology-based delivery systems have been tested for overcoming this barrier and releasing related drugs into the brain matrix. In this review, nanoparticles (NPs) from simple to developed delivery systems are discussed for the delivery of a drug to the brain. This review particularly focuses on polymeric nanomaterials that have been used for CNS treatment. Polymeric NPs such as polylactide (PLA), poly (D, L-lactide-co-glycolide) (PLGA), poly (ε-caprolactone) (PCL), poly (alkyl cyanoacrylate) (PACA), human serum albumin (HSA), gelatin, and chitosan are discussed in detail.

Original languageEnglish
Article number13
JournalBiomedicines
Volume8
Issue number1
Early online date13 Jan 2020
DOIs
Publication statusFirst published - 13 Jan 2020
Externally publishedYes

Keywords

  • Central nervous system (CNS)
  • Drug delivery systems
  • Lood-brain barrier (BBB)
  • Nanotechnology
  • Polymeric nanoparticles
  • Theranostics

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    Shakeri, S., Ashrafizadeh, M., Zarrabi, A., Roghanian, R., Afshar, E. G., Pardakhty, A., Mohammadinejad, R., Kumar, A., & Thakur, V. K. (2020). Multifunctional polymeric nanoplatforms for brain diseases diagnosis, therapy and theranostics. Biomedicines, 8(1), [13]. https://doi.org/10.3390/biomedicines8010013