TY - JOUR
T1 - Multifunctional polymeric nanoplatforms for brain diseases diagnosis, therapy and theranostics
AU - Shakeri, Shahryar
AU - Ashrafizadeh, Milad
AU - Zarrabi, Ali
AU - Roghanian, Rasoul
AU - Afshar, Elham Ghasemipour
AU - Pardakhty, Abbas
AU - Mohammadinejad, Reza
AU - Kumar, Anuj
AU - Thakur, Vijay Kumar
PY - 2020/1/13
Y1 - 2020/1/13
N2 - The blood-brain barrier (BBB) acts as a barrier to prevent the central nervous system (CNS) from damage by substances that originate from the blood circulation. The BBB limits drug penetration into the brain and is one of the major clinical obstacles to the treatment of CNS diseases. Nanotechnology-based delivery systems have been tested for overcoming this barrier and releasing related drugs into the brain matrix. In this review, nanoparticles (NPs) from simple to developed delivery systems are discussed for the delivery of a drug to the brain. This review particularly focuses on polymeric nanomaterials that have been used for CNS treatment. Polymeric NPs such as polylactide (PLA), poly (D, L-lactide-co-glycolide) (PLGA), poly (ε-caprolactone) (PCL), poly (alkyl cyanoacrylate) (PACA), human serum albumin (HSA), gelatin, and chitosan are discussed in detail.
AB - The blood-brain barrier (BBB) acts as a barrier to prevent the central nervous system (CNS) from damage by substances that originate from the blood circulation. The BBB limits drug penetration into the brain and is one of the major clinical obstacles to the treatment of CNS diseases. Nanotechnology-based delivery systems have been tested for overcoming this barrier and releasing related drugs into the brain matrix. In this review, nanoparticles (NPs) from simple to developed delivery systems are discussed for the delivery of a drug to the brain. This review particularly focuses on polymeric nanomaterials that have been used for CNS treatment. Polymeric NPs such as polylactide (PLA), poly (D, L-lactide-co-glycolide) (PLGA), poly (ε-caprolactone) (PCL), poly (alkyl cyanoacrylate) (PACA), human serum albumin (HSA), gelatin, and chitosan are discussed in detail.
KW - Central nervous system (CNS)
KW - Drug delivery systems
KW - Lood-brain barrier (BBB)
KW - Nanotechnology
KW - Polymeric nanoparticles
KW - Theranostics
UR - http://www.scopus.com/inward/record.url?scp=85078845050&partnerID=8YFLogxK
U2 - 10.3390/biomedicines8010013
DO - 10.3390/biomedicines8010013
M3 - Review article
C2 - 31941057
AN - SCOPUS:85078845050
SN - 2227-9059
VL - 8
JO - Biomedicines
JF - Biomedicines
IS - 1
M1 - 13
ER -
