Murine cecal patch M cells transport infectious prions in vivo

Neil Foster*, Gordon G. MacPherson

*Corresponding author for this work

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We show that following oral inoculation, prions bind to ileal Peyer patch and cecal patch microfold cells (M cells) in vivo. Furthermore, we show evidence that the cecum acts a biological sump holding large concentrations of prions for relatively long periods, thus increasing the exposure time of cecal patch M cells. Our results show a critical initial step in the translocation of prions from the intestinal lumen of mammals in vivo, which is a precursor to infection.

Original languageEnglish
Pages (from-to)1916-1919
Number of pages4
JournalJournal of Infectious Diseases
Volume202
Issue number12
DOIs
Publication statusPrint publication - 15 Dec 2010
Externally publishedYes

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