Abstract
We show that following oral inoculation, prions bind to ileal Peyer patch and cecal patch microfold cells (M cells) in vivo. Furthermore, we show evidence that the cecum acts a biological sump holding large concentrations of prions for relatively long periods, thus increasing the exposure time of cecal patch M cells. Our results show a critical initial step in the translocation of prions from the intestinal lumen of mammals in vivo, which is a precursor to infection.
Original language | English |
---|---|
Pages (from-to) | 1916-1919 |
Number of pages | 4 |
Journal | Journal of Infectious Diseases |
Volume | 202 |
Issue number | 12 |
DOIs | |
Publication status | Print publication - 15 Dec 2010 |
Externally published | Yes |