Murine cecal patch M cells transport infectious prions in vivo

Neil Foster; Gordon G. MacPherson

doi:10.1086/657415

Murine cecal patch M cells transport infectious prions in vivo

Neil Foster^*
, Gordon G. MacPherson

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

We show that following oral inoculation, prions bind to ileal Peyer patch and cecal patch microfold cells (M cells) in vivo. Furthermore, we show evidence that the cecum acts a biological sump holding large concentrations of prions for relatively long periods, thus increasing the exposure time of cecal patch M cells. Our results show a critical initial step in the translocation of prions from the intestinal lumen of mammals in vivo, which is a precursor to infection.

Original language	English
Pages (from-to)	1916-1919
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	202
Issue number	12
DOIs	https://doi.org/10.1086/657415
Publication status	Print publication - 15 Dec 2010
Externally published	Yes

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10.1086/657415

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title = "Murine cecal patch M cells transport infectious prions in vivo",

abstract = "We show that following oral inoculation, prions bind to ileal Peyer patch and cecal patch microfold cells (M cells) in vivo. Furthermore, we show evidence that the cecum acts a biological sump holding large concentrations of prions for relatively long periods, thus increasing the exposure time of cecal patch M cells. Our results show a critical initial step in the translocation of prions from the intestinal lumen of mammals in vivo, which is a precursor to infection.",

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AU - MacPherson, Gordon G.

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AB - We show that following oral inoculation, prions bind to ileal Peyer patch and cecal patch microfold cells (M cells) in vivo. Furthermore, we show evidence that the cecum acts a biological sump holding large concentrations of prions for relatively long periods, thus increasing the exposure time of cecal patch M cells. Our results show a critical initial step in the translocation of prions from the intestinal lumen of mammals in vivo, which is a precursor to infection.

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Murine cecal patch M cells transport infectious prions in vivo

Abstract

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