Myostatin dysfunction is associated with reduction in overload induced hypertrophy of soleus muscle in mice

P Minderis, A Kilikevicius, J Baltusnikas, Y Alhindi, T Venckunas, L Bunger, A Lionikas, A Ratkevicius*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)
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Abstract

The aim of the study was to investigate if myostatin dysfunction would promote the gain in muscle mass and peak isometric force (P0 ) of soleus muscle (SOL) in response to functional overloading (FO) after ablation of the gastrocnemius muscle. Fifteen male Berlin high (BEH) mice homozygous for the compact mutation causing dysfunction of myostatin and 17 mice with the corresponding wild-type allele (BEH+/+) were subjected to FO of SOL for 28 days at the age of 14 weeks. Compared with BEH+/+ mice, SOL of BEH was heavier (mean ± SD, 13.5 ± 1.5 vs 21.4 ± 1.8 mg, respectively, P < 0.001). After FO, SOL mass increased relatively more in BEH+/+ than BEH strain (34.9 ± 11.5 vs 17.7 ± 11.9%, respectively, P < 0.01). P0 fell (P < 0.01) only in BEH strain, which also showed an increase (P < 0.01) in optimal muscle length. Specific P0 became even more depressed in BEH compared with BEH+/+ strain (8.4 ± 1.4 vs 10.8 ± 1.3 N/g, respectively, P < 0.001). Phosphorylation p70 S6 kinase did not differ between the strains. In summary, myostatin dysfunction impairs adaptation of SOL muscle to high functional demands.
Original languageEnglish
Pages (from-to)894 - 901
Number of pages8
JournalScandinavian Journal of Medicine Science in Sports
Volume26
Issue number8
DOIs
Publication statusPrint publication - 2015

Bibliographical note

1023378

Keywords

  • Contractile properties
  • High resistance movement
  • Muscle hypertrophy
  • Skeletal muscle
  • p70S6K

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