Nanomaterials in the management of gram-negative bacterial infections

Mahmood Barani, Mahira Zeeshan, Davood Kalantar-Neyestanaki, Muhammad Asim Farooq, Abbas Rahdar*, Niraj Kumar Jha, Saman Sargazi, Piyush Kumar Gupta, Vijay Kumar Thakur

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

The exploration of multiplexed bacterial virulence factors is a major problem in the early stages of Escherichia coli infection therapy. Traditional methods for detecting Escherichia coli (E. coli), such as serological experiments, immunoassays, polymerase chain reaction, and isothermal micro-calorimetry have some drawbacks. As a result, detecting E. coli in a timely, cost-effective, and sensitive manner is critical for various areas of human safety and health. Intelligent devices based on nanotechnology are paving the way for fast and early detection of E. coli at the point of care. Due to their specific optical, magnetic, and electrical capabilities, nanostructures can play an important role in bacterial sensors. Another one of the applications involved use of nanomaterials in fighting mi-crobial infections, including E. coli mediated infections. Various types of nanomaterials, either used directly as an antibacterial agent such as metallic nanoparticles (NPs) (silver, gold, zinc, etc.), or as a nanocarrier to deliver and target the antibiotic to the E. coli and its infected area. Among different types, polymeric NPs, lipidic nanocarriers, metallic nanocarriers, nanomicelles, nanoemulsion/ nanosuspension, dendrimers, graphene, etc. proved to be effective vehicles to deliver the drug in a controlled fashion at the targeted site with lower off-site drug leakage and side effects.

Original languageEnglish
Article number2535
JournalNanomaterials
Volume11
Issue number10
Early online date28 Sep 2021
DOIs
Publication statusPrint publication - Oct 2021

Keywords

  • Diagnosis
  • Escherichia coli
  • Infection
  • Nanotechnology
  • Treatment

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